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T cell differentiation (view source)
Revision as of 13:41, 9 September 2008
, 13:41, 9 September 2008→Antigen Presentation by Dendritic Cells
*Veiled cells enter the paracortical region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] where they present antigen to [[Lymphocytes - WikiBlood#T cells|T cells]]. They are now called '''Interdigitating Dendritic Cells'''
*Veiled cells enter the paracortical region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] where they present antigen to [[Lymphocytes - WikiBlood#T cells|T cells]]. They are now called '''Interdigitating Dendritic Cells'''
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'''Dendritic Cells'''
'''Dendritic Cells'''
*There are two different lineages of dendritic cells:
*There are two different lineages of dendritic cells:
**From myeloid precursor cells
**From myeloid precursor cells
**From plasmacytoid precursor cells
**From plasmacytoid precursor cells
*Stimulate a primary T cell response
*Stimulate a primary T cell response
*Migrate through tissues, track to [[Lymphocytes - WikiBlood#T cells|T cells]] dependent areas of [[Lymph Nodes - Anatomy & Physiology|lymph node]] and cluster with [[Lymphocytes - WikiBlood#T cells|T cells]]
*Migrate through tissues, track to [[Lymphocytes - WikiBlood#T cells|T cells]] dependent areas of [[Lymph Nodes - Anatomy & Physiology|lymph node]] and cluster with [[Lymphocytes - WikiBlood#T cells|T cells]]
*Cell-surface expression pattern according to their differentiation/maturation/activation
*Cell-surface expression pattern according to their differentiation/maturation/activation
*Main function is priming of [[Lymphocytes - WikiBlood#T cells|T helper cells]]
*Main function is priming of [[Lymphocytes - WikiBlood#T cells|T helper cells]]
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[[Image:Maturation of Dendritic Cells.jpg|thumb|right|150px|Maturation of Dendritic Cells - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]
'''Maturation signals'''
*Exogenous
**Bacteria or their products (LPS, LTA, lipoproteins)
**Viruses or their products (dsRNA, G-RSV)
**Protozoa or their products
**Helminths (SEA, ES 62)
*Endogenous
**Inflammatory mediators (IL-1/TNF-a, hsp, FcR)
**Immune cells (CD40L, CD47, FasL)
==TH<sub>1</sub> Cells==
==TH<sub>1</sub> Cells==