Difference between revisions of "Type II Hypersensitivity"
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| + | |backcolour = FFE4E1 | ||
| + | |linkpage =Immunology - WikiBlood | ||
| + | |linktext =IMMUNOLOGY | ||
| + | |sublink1 =Hypersensitivity - WikiBlood | ||
| + | |subtext1 =HYPERSENSITIVITY | ||
| + | |pagetype =Blood | ||
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| + | [[Image:Type II Hypersensitivity.jpg|right|thumb|150px|Type II Hypersensitivity-Brian Catchpole RVC 2008]] | ||
==Introduction== | ==Introduction== | ||
| − | + | ||
| − | Production of [[Immunoglobulin M|IgM]] or [[Immunoglobulin G|IgG]] to cell surface antigens or extracellular matrix proteins. | + | Production of [[Immunoglobulin M - WikiBlood|IgM]] or [[Immunoglobulin G - WikiBlood|IgG]] to cell surface antigens or extracellular matrix proteins. |
==Mechanism== | ==Mechanism== | ||
| + | |||
''' "Neutralisation" blockade of receptors:''' | ''' "Neutralisation" blockade of receptors:''' | ||
| − | * Antibodies attach to receptors | + | * Antibodies attach to receptors which prevents other molecules attaching. |
* For example in myasthenia gravis antibodies attach to acetylcholine receptors which in turn prevents acetylcholine from attaching to the receptor and thus muscle contraction of that cell does not occur. | * For example in myasthenia gravis antibodies attach to acetylcholine receptors which in turn prevents acetylcholine from attaching to the receptor and thus muscle contraction of that cell does not occur. | ||
| + | |||
''' Immunological attack on target cells, destroying them by (see diagram):''' | ''' Immunological attack on target cells, destroying them by (see diagram):''' | ||
| − | [[Adaptive Immunity to Viruses|1. Antibody dependent cell cytotoxicity (ADCC)]] | + | [[Adaptive Immune System - WikiBlood#Adaptive Immunity to Viruses|1. Antibody dependent cell cytotoxicity (ADCC)]] |
| − | * [[Pemphigus|Pemphigus vulgaris]] | + | * [[Autoimmune Diseases - WikiBlood#5. Pemphigus Vulgaris|Pemphigus vulgaris]] |
| − | * [[Bullous Pemphigoid|Bullous pemphigoid]] | + | * [[Autoimmune Diseases - WikiBlood#4. Bullous Pemphigoid|Bullous pemphigoid]] |
| − | 2. [[Complement|Complement]] mediated lysis | + | 2. [[Complement - WikiBlood|Complement]] mediated lysis |
| − | * Self [[Erythrocytes|RBC]] antigen: | + | * Self [[Erythrocytes - WikiBlood|RBC]] antigen: |
| − | ** [[Immune Mediated Haemolytic Anaemia|Immune mediated haemolytic anaemia]] | + | ** [[Autoimmune Diseases - WikiBlood#1. Immune Mediated Haemolytic Anaemia (IMHA)|Immune mediated haemolytic anaemia]] |
| − | * Foreign [[Erythrocytes|RBC]]: | + | * Foreign [[Erythrocytes - WikiBlood|RBC]]: |
** Blood transfusion reaction | ** Blood transfusion reaction | ||
| − | ** [[ | + | ** [[Materno-fetal immunity - WikiBlood#Alloimmune haemalytic anaemia of the newborn|Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)]] |
* RBC parasite: | * RBC parasite: | ||
** Feline infectious anaemia (''Mycoplasma haemofelis'') | ** Feline infectious anaemia (''Mycoplasma haemofelis'') | ||
3. Phagocytosis | 3. Phagocytosis | ||
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Revision as of 10:45, 19 September 2008
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This article has been peer reviewed but is awaiting expert review. If you would like to help with this, please see more information about expert reviewing. |
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Introduction
Production of IgM or IgG to cell surface antigens or extracellular matrix proteins.
Mechanism
"Neutralisation" blockade of receptors:
- Antibodies attach to receptors which prevents other molecules attaching.
- For example in myasthenia gravis antibodies attach to acetylcholine receptors which in turn prevents acetylcholine from attaching to the receptor and thus muscle contraction of that cell does not occur.
Immunological attack on target cells, destroying them by (see diagram):
1. Antibody dependent cell cytotoxicity (ADCC)
2. Complement mediated lysis
- Self RBC antigen:
- Foreign RBC:
- Blood transfusion reaction
- Haemolytic disease of new born (Rhesus disease in humans and neonatal isoerythrolysis in foals and kittens)
- RBC parasite:
- Feline infectious anaemia (Mycoplasma haemofelis)
3. Phagocytosis