Difference between revisions of "Trimethoprim - Dihydrofolate Reductase Inhibitors"
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(New page: {{unfinished}} {{toplink |linkpage =WikiDrugs |linktext =WikiDrugs |sublink1 = Antibiotics |subtext1 = Antibiotics |pagetype = Drugs }} [[Image: Trimethoprim.png|thumb|right|250px|Trimeth...) |
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[[Image: Trimethoprim.png|thumb|right|250px|Trimethoprim]] | [[Image: Trimethoprim.png|thumb|right|250px|Trimethoprim]] | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
| − | + | Sulphonamides act by competing with an essential precursor in folic acid synthesis in bacteria. Bacteria need to synthesise folic acid in order to grow as they are unable to obtain it from their 'diet' like mammals can. Since the bacteria is unable to synthesise RNA or DNA, due to it's lack of folic acid, it's growth is inhibited. As such sulphonamides are '''bacteriostatic'''. | |
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==Spectrum of Activity== | ==Spectrum of Activity== | ||
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==Pharmacokinetic Considerations== | ==Pharmacokinetic Considerations== | ||
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==Side Effects and Contraindications== | ==Side Effects and Contraindications== | ||
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Revision as of 12:50, 24 October 2008
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This article is still under construction. |
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Mechanism of Action
Sulphonamides act by competing with an essential precursor in folic acid synthesis in bacteria. Bacteria need to synthesise folic acid in order to grow as they are unable to obtain it from their 'diet' like mammals can. Since the bacteria is unable to synthesise RNA or DNA, due to it's lack of folic acid, it's growth is inhibited. As such sulphonamides are bacteriostatic.