Difference between revisions of "Chloramphenicol"
Jump to navigation
Jump to search
| Line 21: | Line 21: | ||
==Pharmacokinetic Considerations== | ==Pharmacokinetic Considerations== | ||
| + | Chloramphenicol and analogues: Highly lipophilic neutral small molecules. | ||
| + | • Orally active. | ||
| + | • Very wide volume of distribution – penetrates across cell membranes readily – the data shown on the slide are for penetration into bronchial secretions. | ||
| − | + | Bronchial fluid is a transcellular fluid – what are the barriers for a drug to diffuse into this fluid? | |
| + | |||
| + | • Hepatic metabolism (varies between species and with age) for chloramphenicol. | ||
| + | • A higher proportion of the administered dose of thiamphenicol and florphenicol are excreted unchanged in the urine. | ||
==Side Effects and Contraindications== | ==Side Effects and Contraindications== | ||
==Florfenicol and Thiamphenicol== | ==Florfenicol and Thiamphenicol== | ||
Revision as of 13:51, 24 October 2008
 |
This article is still under construction. |
|
Mechanism of Action
Spectrum of Activity
Pharmacokinetic Considerations
Chloramphenicol and analogues: Highly lipophilic neutral small molecules. • Orally active. • Very wide volume of distribution – penetrates across cell membranes readily – the data shown on the slide are for penetration into bronchial secretions.
Bronchial fluid is a transcellular fluid – what are the barriers for a drug to diffuse into this fluid?
• Hepatic metabolism (varies between species and with age) for chloramphenicol. • A higher proportion of the administered dose of thiamphenicol and florphenicol are excreted unchanged in the urine.