Difference between revisions of "Skin Other - Pathology"
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| + | |linkpage =Integumentary System - Pathology | ||
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| + | |maplink = Integumentary System (Content Map) - Pathology | ||
| + | |pagetype =Pathology | ||
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| + | ==Epidermal growth or differentiation disorders== | ||
| + | |||
| + | ===Seborrheic disease complex=== | ||
| + | *Abnormal cornification or function of sebaceous glands | ||
| + | *Large amounts of free fatty acids and cholesterol | ||
| + | *Decreased amounts of diester waxes in surface lipids | ||
| + | *Bacterial population changes to pathogenic [[Staphylococcus spp.|coagulase positive staphylococci]] | ||
| + | *Chronic disease affecting mainly dogs, sometimes cats and horses | ||
| + | *Dry form - white to grey scales | ||
| + | *Greasy form - scaly, excess brown to yellow lipids sticking to skin and hair | ||
| + | |||
| + | ===Primary idiopathic seborrhea=== | ||
| + | *Abnormal cornification | ||
| + | *Epidermal turnover reduced to about 2/3 of normal | ||
| + | *Microscopically: | ||
| + | **Hyperkeratosis distending follicular ostia causing papillary appearance | ||
| + | **Parakeratosis at edges of follicular ostia | ||
| + | **Congested, oedematous dermal papillae | ||
| + | **Spongiotic epidermis with leukocytes | ||
| + | |||
| + | ===Secondary seborrhea=== | ||
| + | *Develops secondarily to many types of disease (''e.g.'' [[Parasitic skin infections - Pathology|ectoparasites]], [[Mycotic skin infections - Pathology|fungal infections]], [[Endocrine effects on the skin - Pathology|endocrine disease]], internal disease or allergy) | ||
| + | *Microscopically: | ||
| + | **Hyperkeratosis and/or parakeratosis of follicles and epidermis | ||
| + | **Lesions relevant to the other disease | ||
| + | |||
| + | ===Sebaceous adenitis=== | ||
| + | *Inflammation of sebaceous glands, alopecia, hyperkeratosis | ||
| + | *Possibly immune-mediated | ||
| + | *Mainly affects dogs | ||
| + | **Long haired show multifocal, serpiginous and annular lesions | ||
| + | *Microscopically: | ||
| + | **Inflammation of sebaceous glands | ||
| + | **Possibly orthokeratotic hyperkeratosis | ||
| + | **Chronic lesions are deprived of sebaceous glands and contain mild inflammation and fibrosis at follicular isthmus | ||
| + | |||
| + | ==Pigmentation disorders== | ||
| + | ===Hypopigmentation=== | ||
| + | *Leukoderma or vitiligo - loss of pigment in the skin | ||
| + | *Leukotrichia - loss of pigment of the hair | ||
| + | *Hypopigmentation or incomplete albinism - generalised reduction of pigment in skin or hair | ||
| + | *Albinism - inherited lack of pigment | ||
| + | *Dilution - reduced pigmentation | ||
| + | *Can be localised or generalised, idiopathic or asociated with other diseases | ||
| + | *Examples of hereditary conditions: Maltese dilution of cats, Chediak-Higashi syndrome, leukoderma and leukotrichia of Dobermans, Arabian fading syndrome | ||
| + | *Asociated with some immune-mediated disorders, ''e.g.'' [[Skin Immunologic - Pathology#Lupus erythematosus|discoid lupus erythematosus]] | ||
| + | |||
| + | ===Hyperpigmentation=== | ||
| + | [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=1782 Image of endocrine hyperpigmentation from Cornell] | ||
| + | *Results from irritation or inflammation, pigmented [[Skin Neoplastic - Pathology|neoplasms]] or [[Endocrine effects on the skin - Pathology|metabolic diseases]] | ||
| + | *Lentigo - circumscribed macular or slightly raised plaque with epidermal hyperplasia and hyperpigmentation | ||
| + | |||
| + | ==Eosinophilic infiltration== | ||
| + | ===Eosinophilic plaques=== | ||
| + | ===Eosinophilic granulomas=== | ||
| + | ===Eosinophilic folliculitis and furunculosis=== | ||
| + | ==Sterile granulomatous disorders== | ||
| + | ===Juvenile pyoderma=== | ||
| + | ===Equine generalised granulomatous disease=== | ||
Revision as of 12:20, 31 October 2008
 |
This article is still under construction. |
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Epidermal growth or differentiation disorders
Seborrheic disease complex
- Abnormal cornification or function of sebaceous glands
- Large amounts of free fatty acids and cholesterol
- Decreased amounts of diester waxes in surface lipids
- Bacterial population changes to pathogenic coagulase positive staphylococci
- Chronic disease affecting mainly dogs, sometimes cats and horses
- Dry form - white to grey scales
- Greasy form - scaly, excess brown to yellow lipids sticking to skin and hair
Primary idiopathic seborrhea
- Abnormal cornification
- Epidermal turnover reduced to about 2/3 of normal
- Microscopically:
- Hyperkeratosis distending follicular ostia causing papillary appearance
- Parakeratosis at edges of follicular ostia
- Congested, oedematous dermal papillae
- Spongiotic epidermis with leukocytes
Secondary seborrhea
- Develops secondarily to many types of disease (e.g. ectoparasites, fungal infections, endocrine disease, internal disease or allergy)
- Microscopically:
- Hyperkeratosis and/or parakeratosis of follicles and epidermis
- Lesions relevant to the other disease
Sebaceous adenitis
- Inflammation of sebaceous glands, alopecia, hyperkeratosis
- Possibly immune-mediated
- Mainly affects dogs
- Long haired show multifocal, serpiginous and annular lesions
- Microscopically:
- Inflammation of sebaceous glands
- Possibly orthokeratotic hyperkeratosis
- Chronic lesions are deprived of sebaceous glands and contain mild inflammation and fibrosis at follicular isthmus
Pigmentation disorders
Hypopigmentation
- Leukoderma or vitiligo - loss of pigment in the skin
- Leukotrichia - loss of pigment of the hair
- Hypopigmentation or incomplete albinism - generalised reduction of pigment in skin or hair
- Albinism - inherited lack of pigment
- Dilution - reduced pigmentation
- Can be localised or generalised, idiopathic or asociated with other diseases
- Examples of hereditary conditions: Maltese dilution of cats, Chediak-Higashi syndrome, leukoderma and leukotrichia of Dobermans, Arabian fading syndrome
- Asociated with some immune-mediated disorders, e.g. discoid lupus erythematosus
Hyperpigmentation
Image of endocrine hyperpigmentation from Cornell
- Results from irritation or inflammation, pigmented neoplasms or metabolic diseases
- Lentigo - circumscribed macular or slightly raised plaque with epidermal hyperplasia and hyperpigmentation