Difference between revisions of "Category:Neurotoxic Clostridia"

From WikiVet English
Jump to navigation Jump to search
(Created page with ' ===''Clostridium tetani''=== ===''Clostridium botulinum''=== *Ubiquitous organism *Oval, subterminal endospores; spores survive boiling for hours *Causes [[Muscles Degen…')
 
(Replaced content with '===''Clostridium tetani''=== ===''Clostridium botulinum''=== Category:Clostridium species')
 
Line 1: Line 1:
 
 
===''[[Clostridium tetani]]''===
 
===''[[Clostridium tetani]]''===
  
  
  
===''Clostridium botulinum''===
+
===''[[Clostridium botulinum]]''===
  
*Ubiquitous organism
+
[[Category:Clostridium species]]
*Oval, subterminal endospores; spores survive boiling for hours
 
*Causes [[Muscles Degenerative - Pathology#Botulism|botulism]], a potentially fatal intoxication
 
*Germination of endospores, growth of bacterial cells and toxin production in anaerobic conditions e.g. decaying carcasses and vegetation
 
*Disease in animals consuming rotting carcasses and in herbivores through contamination of feed
 
*Pathogenesis:
 
**Intoxication on ingestion and absorbtion of toxin from GIT into the blood
 
**Occasionally germination of spores in wounds or GIT
 
**Neurotoxin carried to peripheral nervous system
 
**Toxin binds gangliosides irreversibly at the neuromuscular junction
 
**Blocks release of acetylcholine
 
*Clinical signs:
 
**Dilated pupils, dry mucus membranes, decreased salivation, tongue flacidity, dysphagia in farm animals
 
**Incoordination and knuckling followed by flacid paralysis and recumbency
 
**Paralysis of respiratory muscles leads to death
 
**Flacid paralysis of legs and wings in birds
 
*Diagnosis:
 
**Mouse inoculation with infected serum
 
**Toxin detection by PCR, ELISA
 
**Toxin neutralisation tests in mice
 
*Treatment: polyvalent antiserum neutralises unbound toxin
 
*Toxoid vaccine used in endemic regions
 
*Implicated in [[Intestine Physical Disturbances - Pathology#Equine dysautonomia, or grass sickness|equine grass sickness]][[Category:Clostridium species]]
 

Latest revision as of 10:47, 12 May 2010

Pages in category "Neurotoxic Clostridia"

The following 2 pages are in this category, out of 2 total.