Difference between revisions of "Category:Paramyxoviridae"

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*Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
 
*Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
 
**These are detected by immunostaining infected cells
 
**These are detected by immunostaining infected cells
 
==Paramyxoviridae by Species==
 
 
==Avian==
 
===[[Newcastle Disease Virus (NDV)]]===
 
 
==Canine==
 
===[[Canine Parainfluenza - 2 (aka Parainfluenza - 5)]]===
 
 
===[[Canine Distemper Virus (CDV)]]===
 
 
==Bovine==
 
===[[Bovine Parainfluenza - 3]]===
 
 
===[[Bovine Respiratory Syncytial Virus]]===
 
 
==Equine==
 
===[[Hendra Virus]]===
 
 
==Porcine==
 
===[[Nipah Virus]]===
 
 
==Reptiles==
 
===[[Reptilian Paramyxoviruses]]===
 
 
==Rodentia==
 
===Murine Parainfluenza - 1 ([[Sendai Virus]])===
 
  
 
=Other resources=
 
=Other resources=

Revision as of 11:36, 22 May 2010



Morphology

  • Single-stranded negative-sense unsegmented RNA virus
  • Reassortment and antigenic shift cannot occur
  • Spike proteins include
    • HN (Haemagglutinin and Neuraminidase)
    • F (Fusion glycoprotein), which allows the virus to fuse directly to the plasma membrane and release its RNA
      • F also causes syncitium to form, which aids diagnosis
      • Host antibody response to the F protein is the basis for vaccination

Virulence

  • Paramyxoviruses replicate in the epithelium of the upper respiratory tract as well as occasionally in the gut
    • Sites of spike protein cleavage
  • Virulence varies by virus, see below

Types and Subtypes

Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including:

Antigenic Variation

  • Antigenic conservation allows some cross protection by vaccination:
    • Conservation of major virus-specific F/HN antigens means vaccines protect against all isolates of the same virus
    • Minor morbillivirus-specific epitopes on F allows some cross protection between canine distemper, measles, and rinderpest
  • Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
    • These are detected by immunostaining infected cells

Other resources

Subcategories

This category has the following 2 subcategories, out of 2 total.

P

Pages in category "Paramyxoviridae"

The following 3 pages are in this category, out of 3 total.