Difference between revisions of "Category:Retroviridae"
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| + | {{frontpage | ||
| + | |pagetitle =Retroviridae | ||
| + | |pagebody = Retroviruses are persistent, non-cytopathic, systemic viruses that give rise to secondary disease, such as tumors, immune-complex disease, or immunosuppression. | ||
| + | |contenttitle =Content | ||
| + | |contentbody =<big><b> | ||
| + | <categorytree mode=pages>Retroviridae</categorytree> | ||
| − | + | BLV-HTLV retroviruses | |
| + | :''Bovine Leukosis Virus'' | ||
| + | |logo =FeLV logo.jpg | ||
| + | }} | ||
| − | = | + | ==Morphology== |
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*Fragile, enveloped RNA viruses with roughly spherical spike proteins | *Fragile, enveloped RNA viruses with roughly spherical spike proteins | ||
*Genome has 3 genes: | *Genome has 3 genes: | ||
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*Both ends of genome show a promoter (LTR: long terminal repeat) | *Both ends of genome show a promoter (LTR: long terminal repeat) | ||
| − | =Antigenicity= | + | ==Antigenicity== |
*Group-specific antigens (gag's) are shared by all isolates of each virus | *Group-specific antigens (gag's) are shared by all isolates of each virus | ||
**This can be exploited by diagnostic tests | **This can be exploited by diagnostic tests | ||
*Lentiviruses show variation by mutation, making vaccination difficult | *Lentiviruses show variation by mutation, making vaccination difficult | ||
| − | =Virulence and Pathogenesis= | + | ==Virulence and Pathogenesis== |
*Replication involves integrating into the host cell genome: | *Replication involves integrating into the host cell genome: | ||
**'''Uncoating''' to release RNA and RT | **'''Uncoating''' to release RNA and RT | ||
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**Insertion of the viral LTR switches on proto-oncogenes in the host cell genome --> tumor production can take years | **Insertion of the viral LTR switches on proto-oncogenes in the host cell genome --> tumor production can take years | ||
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[[Category:Viruses]] | [[Category:Viruses]] | ||
Revision as of 13:06, 23 May 2010
Retroviridae
Retroviruses are persistent, non-cytopathic, systemic viruses that give rise to secondary disease, such as tumors, immune-complex disease, or immunosuppression.
Content
BLV-HTLV retroviruses
- Bovine Leukosis Virus
Morphology
- Fragile, enveloped RNA viruses with roughly spherical spike proteins
- Genome has 3 genes:
- gag: group-specific antigen coding gene, encodes capsid proteins
- pol: encodes reverse transcriptase (RT) and integrase
- env: encodes envelope spikes, and can be used in diagnosis and subunit vaccines
- Both ends of genome show a promoter (LTR: long terminal repeat)
Antigenicity
- Group-specific antigens (gag's) are shared by all isolates of each virus
- This can be exploited by diagnostic tests
- Lentiviruses show variation by mutation, making vaccination difficult
Virulence and Pathogenesis
- Replication involves integrating into the host cell genome:
- Uncoating to release RNA and RT
- +RNA transcribed to -DNA by RT
- -DNA becomes circular dsDNA and is integrated into host chromosome by integrase
- DNA codes for viral proteins using cellular organelles and enzymes
- Because of this technique, virus replication is much slower, and retroviruses can remain latent
- Tumor production takes 2 forms:
- Viruses can carry oncogenes within their genome --> tumor production occurs quickly
- Insertion of the viral LTR switches on proto-oncogenes in the host cell genome --> tumor production can take years
Subcategories
This category has the following 3 subcategories, out of 3 total.
Pages in category "Retroviridae"
The following 4 pages are in this category, out of 4 total.