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Category:Oral Cavity - Proliferative Pathology (view source)
Revision as of 15:27, 25 May 2010
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===Hyperplastic===
====[[Polychlorinated Napthalene Poisoning]]====
===Papular===
====Orf====
*[[Poxviridae|Pox]] infection
*Quite a common '''zoonotic''' disease
Papular proliferative pathology
=====Clinical=====
*In sheep produces a proliferative nodule/papular mass on [[Lips - Anatomy & Physiology|lips]]
*In flocks in which it is endemic it is seen in lamb
*If flock is non-immune seen in ewes too but much worse in lambs (may spread to inside of mouth)
*Can spread to udder of ewe
=====Pathology=====
*Poxvirus infections produce local infection of [[prickle cells]] in epithelium with proliferation of cells and formation of papule followed by ulceration / necrosis and covered by necrotic epithelium
*Eventually scabs form and crust drops off
*Scabs - very infectious ( N.B.if touch -> catch it)
====Bovine Papular stomatitis====
[[Image:BPS.gif|right|thumb|125px|<small><center>Ring Zone Lesions of BPS - Calf (Courtesy of Alun Williams (RVC))</center></small>]]
*Parapox virus
*Very similar disease to orf but seen in cattle and generally milder condition.
*'''Must be differentiated from [[#Foot and Mouth disease|Foot and Mouth Disease]] and [[#Bovine Viral Diarrhoea / Mucosal disease|Mucosal Disease.]]'''
*Sporadic, in cattle, less than 1 year old.
*Develop papules on the muzzle, external nares and in the [[Oral Cavity Overview - Anatomy & Physiology|oral cavity]]; the [[Oesophagus - Anatomy & Physiology|oesophagus]] and [[Stomach and Abomasum - Anatomy & Physiology|forestomachs]] may also be affected.
*Usually heals spontaneously.
=====Pathogenesis=====
*The early lesions are round areas of intense congestion up to 1.5 cm in diameter.
*The centre becomes necrotic and slightly depressed.
*Slow peripheral extension of this lesion gives a classical ring zone formation with concentric rings of
**yellow (necrosis),
**grey (epithelial hyperplasia)
**red (congestion).
=====Histology=====
*There are focal areas of hydropic degeneration in the stratum spinosum
*Large eosinophilic intracytoplasmic inclusion
*Epidermis is markedly thickened.
*The superficial layers of the epithelium become necrotic and slough.
*''Vesicle formation is not a feature of this disease.''
====Papilloma====
===Neoplastic===
====Squamous cell carcinoma====
[[Image:oral squamous cell carcinoma.jpg|right|thumb|125px|<small><center>'''Oral squamous cell carcinoma'''. Courtesy of T. Scase</center></small>]] neoplastic
[[Category:Oral_Cavity_and_Gingiva_-_Pathology]]