Difference between revisions of "Mucormycosis"

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(Created page with '{{review}} Granulomatous inflammation * ''Mucor'', a fungi, invades the rumen wall, e.g. after damage caused by [[Rumenal Acidosis|rumenal …')
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{{review}}
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Granulomatous inflammation
 
Granulomatous inflammation
  
* ''Mucor'', a fungi, invades the [[Rumen - Anatomy & Physiology|rumen]] wall, e.g. after damage caused by rumenal acidosis.
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* ''Mucor'', a fungi, invades the [[The Rumen - Anatomy & Physiology|rumen]] wall, e.g. after damage caused by [[Rumenal Acidosis|rumenal acidosis]].
 
* Produces chronic ongoing granulomatous rumenitis.   
 
* Produces chronic ongoing granulomatous rumenitis.   
 
* Difficult to diagnose in life.
 
* Difficult to diagnose in life.
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=====Gross=====
 
=====Gross=====
  
* Thickening and ulceration of mucosal surface of [[Rumen - Anatomy & Physiology|rumen]].
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* Thickening and ulceration of mucosal surface of [[The Rumen - Anatomy & Physiology|rumen]].
 
** Feels like thick leather.   
 
** Feels like thick leather.   
*[[Rumen - Anatomy & Physiology|Rumen]] wall becomes fibrosed.
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*[[The Rumen - Anatomy & Physiology|Rumen]] wall becomes fibrosed.
  
 
=====Histological=====  
 
=====Histological=====  
  
 
* Classical granulomatous inflammation
 
* Classical granulomatous inflammation
** May have giant cells in addition to sheets of [[Macrophages|macrophages]].
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** May have giant cells in addition to sheets of [[Macrophages - WikiBlood|macrophages]].
 
* Can visualise fungal hyphae in tissue using special stains (PAS),
 
* Can visualise fungal hyphae in tissue using special stains (PAS),
 
** Often grow along blood vessels.
 
** Often grow along blood vessels.
*** May cause thrombosis of small blood vessels, leading to further necrosis (infarction) of [[Rumen - Anatomy & Physiology|rumen]] wall.
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*** May cause thrombosis of small blood vessels, leading to further necrosis (infarction) of [[The Rumen - Anatomy & Physiology|rumen]] wall.[[Category:Forestomach_-_Inflammatory_Pathology]][[Category:Cattle]]
 
 
 
 
 
 
<br>
 
Caused by a fungus of the ''Mucoracae'' family.  Causes a granulomatous rumenitis in cattle with sheets of macrophages and '''giant cells''' vvisble on histopathology.  Grossly the rumen is thickened and fibrosed and may become ulcerated.
 
 
 
The infection may penetrate the rumen wall leading to a peritonitis.  It may also enter blood vessels leading to a thrombosis, infarction and further damage to the vessel wall. 
 
 
 
Fungal hyphae are identified histologically with the stain PAS (Periodic acid Schiff) where they stain as purple/red rod like structures.
 
 
 
 
 
[[Category:Forestomach_-_Inflammatory_Pathology]][[Category:Gastric Diseases - Cattle]]
 
[[Category:To_Do_-_Alimentary]][[Category:To Do - Medium]]
 
[[Category:Arterial_Pathology]]
 
[[Category:Cardiology Section]]
 

Revision as of 12:04, 29 May 2010


Granulomatous inflammation

  • Mucor, a fungi, invades the rumen wall, e.g. after damage caused by rumenal acidosis.
  • Produces chronic ongoing granulomatous rumenitis.
  • Difficult to diagnose in life.
  • May produce pain and poor growth
  • Infective process may penetrate wall and produce peritonitis.

Pathology

Gross
  • Thickening and ulceration of mucosal surface of rumen.
    • Feels like thick leather.
  • Rumen wall becomes fibrosed.
Histological
  • Classical granulomatous inflammation
    • May have giant cells in addition to sheets of macrophages.
  • Can visualise fungal hyphae in tissue using special stains (PAS),
    • Often grow along blood vessels.
      • May cause thrombosis of small blood vessels, leading to further necrosis (infarction) of rumen wall.