Difference between revisions of "Category:Liver - Proliferative Pathology"

Revision as of 14:18, 8 June 2010

Especially in the dog, the liver is frequently affeced by both primary and secondary neoplasms.

Secondary tumours

Secondary metastatic involvement of the liver is very common
in the dog, malignant pancreatic and splenic tumours commonly metastasise to the liver

Melanomas

uveal melanoma in the cat

Lymphosarcoma

the most common secondary malignancy
can be present as nodules or be diffuse infiltration along the portal tracts

Gross

enlarged liver
turgid and friable
many minute pale foci
diffusely pale

Microscopically

tumour cells are seen to spread diffusely through the sinusoids

Carcinomas

from a variety of origins

Sarcomas

Mast cell tumours

Subcategories

This category has the following 2 subcategories, out of 2 total.

L

► Liver, Primary Tumours‎ (3 P)
► Liver, Secondary Tumours‎ (5 P)

Pages in category "Liver - Proliferative Pathology"

The following 2 pages are in this category, out of 2 total.

H

Hepatic Neoplasia

L

Liver - Nodular Hyperplasia

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 Especially in the dog, the [[Liver - Anatomy & Physiology|liver]] is frequently affeced by both primary and secondary neoplasms.
-==Primary tumours==
-*not as common as secondary tumours
-*may arise from each of the four main tissues within the [[Liver - Anatomy & Physiology|liver]]
-**[[Liver - Anatomy & Physiology|liver]] parenchymal cells
-***hepatoma
-***[[Liver - Anatomy & Physiology|liver]] cell carcinoma
-**bile ducts
-***cholangioma
-***bile duct carcinoma
-**blood vessels
-***haemangioma
-***haemangiosarcoma
-**connective tissue
-***fibroma
-***sarcoma
-NB: [[Liver - Anatomy & Physiology|liver]] cell tumours and malignant bile duct tumours are the two most common primary hepatic neoplasms
-===Hepatocytic===
-*[[Liver - Anatomy & Physiology|liver]] cell tumours are usually seen as discrete masses within the [[Liver - Anatomy & Physiology|liver]] parenchyma
-*the tumour tissue is usually reddish brown in colour
-*can be malignant, metastases occuring tothe local [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and lungs
-====Adenoma====
-*seen mostly in sheep and cattle
-=====Gross=====
-*a single, pale, soft, often large nodule
-*well demarcated from adjacent tissue, often with a noticeable capsule
-=====Microscopically=====
-*normal hepatocytic appearance
-*no portal tracts within the mass
-*a capsule surrounds the growth
-====Carcinoma====
-*more in dogs and cats
-=====Gross=====
-*can be difficult to distinguish grossly from adenomas
-*usually one single large mass and additional smaller masses (intrahepatic metastases)
-*may have features of malignancy such as internal necrosis and haemorrhage
-=====Microscopically=====
-*can be very variable appearing as sheets or cords of neoplastic cells
-*cells generally smaller with a higher nucleus to cytoplasmic ratio
-===Cholangiocellular - bile duct===
-====Adenoma====
-*very rare
-*reported in dogs and cats
-====Carcinoma====
-*more common
-*reported in all species (mostly dogs and cats)
-=====Gross=====
-*usually multiple whitish umbilicated nodules that are present diffusely throughout the [[Liver - Anatomy & Physiology|liver]]
-**actually look as though they were secondary tumours
-*firm on cut surface
-**due to fibrosis
-=====Microscopically=====
-*distinctly adenocarcinomatous
-*ductal and acinar proliferation in abundant fibrous tissue
-*sometimes papillary formations
-===Haemangiosarcoma===
-*can be primary in the [[Liver - Anatomy & Physiology|liver]]
-*other predilection sites
-**[[Spleen - Anatomy & Physiology|spleen]]
-**right auricle of the heart
-*prevalent in large breeds
 ==Secondary tumours==