Difference between revisions of "Endocrine Pancreas - Pathology"
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| + | ==[[Pancreas, Endocrine - Degenerative Pathology]]== | ||
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| + | ==Neoplasia== | ||
| + | |||
| + | ===[[Insulin Secreting Neoplasms]]=== | ||
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| + | |||
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| + | [[Insulinoma]] | ||
| + | |||
| + | ===[[Carcinoma]]s=== | ||
| + | |||
| + | ===Gastrinoma=== | ||
| + | [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine] | ||
| + | *Described in dogs, cats | ||
| + | *Known as Zollinger-Ellison syndrome in humans | ||
| + | *Uncommon compared to beta cell neoplasms | ||
| + | *Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and [[Duodenum - Anatomy & Physiology|duodenal]] ulceration | ||
| + | ====Clinical signs==== | ||
| + | *Anorexia | ||
| + | *Severe weight loss | ||
| + | *[[Control of Feeding - Anatomy & Physiology#The Vomit Reflex|Vomiting]] | ||
| + | *[[Diarrhoea]] | ||
| + | *Dehydration | ||
| + | ====Pathology==== | ||
| + | *Multiple variably sized neoplasms | ||
| + | *Increased connective tissue mass - firm | ||
| + | *Partiallty encapsulated | ||
| + | *Invade locally | ||
| + | *Metastases to [[Liver - Anatomy & Physiology|liver]] and local lymph nodes are common | ||
| + | |||
| + | ===Glucagonoma=== | ||
| + | *Very rare | ||
| + | *Characterised by | ||
| + | **Hyperglycaemia | ||
| + | **Vacuolar hepatopathy | ||
| + | **Skin erythema with superficial necrotising dermatitis | ||
| + | *Diagnosis in dogs is difficult as presents together with [[DM|DM]] | ||
| + | <br> | ||
Revision as of 13:39, 9 June 2010
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Pancreas, Endocrine - Degenerative Pathology
Neoplasia
Insulin Secreting Neoplasms
Carcinomas
Gastrinoma
Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine
- Described in dogs, cats
- Known as Zollinger-Ellison syndrome in humans
- Uncommon compared to beta cell neoplasms
- Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration
Clinical signs
Pathology
- Multiple variably sized neoplasms
- Increased connective tissue mass - firm
- Partiallty encapsulated
- Invade locally
- Metastases to liver and local lymph nodes are common
Glucagonoma
- Very rare
- Characterised by
- Hyperglycaemia
- Vacuolar hepatopathy
- Skin erythema with superficial necrotising dermatitis
- Diagnosis in dogs is difficult as presents together with DM