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Immunodeficiencies - WikiBlood (view source)
Revision as of 12:28, 12 June 2010
, 12:28, 12 June 2010Text replace - 'Neutrophils - WikiBlood' to 'Neutrophils'
*Occurs in Irish Setters
*Occurs in Irish Setters
*Missence mutation of -Cys-36-Ser- in CD18 molecule
*Missence mutation of -Cys-36-Ser- in CD18 molecule
**CD18 is required for [[Neutrophils - WikiBlood|neutrophil]] migration and phagocytosis
**CD18 is required for [[Neutrophils|neutrophil]] migration and phagocytosis
*Recurrent bacterial infection
*Recurrent bacterial infection
*Neutrophilia ([[Neutrophils - WikiBlood|neutrophils]] remain in the blood and are unable to fight infection in the tissue)
*Neutrophilia ([[Neutrophils|neutrophils]] remain in the blood and are unable to fight infection in the tissue)
====Bovine Leukocyte Adhesion Deficiency (BLAD)====
====Bovine Leukocyte Adhesion Deficiency (BLAD)====
*Inherited defects
*Inherited defects
*Low levels of circulating [[Immunoglobulin M - WikiBlood|IgM]] and [[Immunoglobulin G - WikiBlood|IgG]]
*Low levels of circulating [[Immunoglobulin M - WikiBlood|IgM]] and [[Immunoglobulin G - WikiBlood|IgG]]
*Impaired [[Neutrophils - WikiBlood|neutrophil]] function
*Impaired [[Neutrophils|neutrophil]] function
*Causes recurrent pyrexia and infections
*Causes recurrent pyrexia and infections
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A - WikiBlood|IgA]]
**E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A - WikiBlood|IgA]]