Changes

*[[Eosinophils|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E - WikiBlood|IgE]]</p>

*[[Eosinophils|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E - WikiBlood|IgE]]</p>

<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G - WikiBlood|IgG]] class.</p>

<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G - WikiBlood|IgG]] class.</p>

<p>For more information on class switching click [[Immunoglobulins - WikiBlood#Immunoglobulin Class Switching|here]]</p>

<p>For more information on class switching click [[Immunoglobulins#Immunoglobulin Class Switching|here]]</p>

==T-Cell Dependent and Independent Responses==

==T-Cell Dependent and Independent Responses==

*T cells produce [[Cytokines - WikiBlood|'''cytokines''']]

*T cells produce [[Cytokines - WikiBlood|'''cytokines''']]

**E.g. IL-4

**E.g. IL-4

*[[Immunoglobulins - WikiBlood#Immunoglobulin Class Switching|Class switching]] occurs from IgM

*[[Immunoglobulins#Immunoglobulin Class Switching|Class switching]] occurs from IgM

*Memory B cells are formed

*Memory B cells are formed

*The log phase will peak after about 10-14 days

*The log phase will peak after about 10-14 days

*The '''Plateau Phase''' will then occur

*The '''Plateau Phase''' will then occur

*[[Immunoglobulins - WikiBlood#Immunoglobulin Class Switching|Class switching]] occurs replacing decresing levels of [[Immunoglobulin M - WikiBlood|IgM]] with [[Immunoglobulin G - WikiBlood|IgG]]

*[[Immunoglobulins#Immunoglobulin Class Switching|Class switching]] occurs replacing decresing levels of [[Immunoglobulin M - WikiBlood|IgM]] with [[Immunoglobulin G - WikiBlood|IgG]]

*Antibody levels will then begin to decline as plasma cells undergo apoptosis

*Antibody levels will then begin to decline as plasma cells undergo apoptosis

*After primary immunisation, it usually takes around 7-10 days for a measurable antibody response to become detectable  

*After primary immunisation, it usually takes around 7-10 days for a measurable antibody response to become detectable  

[[Leukopoiesis#Lymphopoiesis|Lymphopoiesis]]

[[Leukopoiesis#Lymphopoiesis|Lymphopoiesis]]

[[Immunoglobulins - WikiBlood|Immunoglobulins]]

[[Immunoglobulins|Immunoglobulins]]