Difference between revisions of "Melioidosis"
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| − | + | (Pseudoglanders) | |
| − | + | *Caused by [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas (Malleomyces) pseudomallei'']], Closely related to [[Burkholderia mallei|''P. mallei'']] in [[Hindgut Fermenters - Horse - Anatomy & Physiology|horses]] | |
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*Causes disease in sheep, goats and pigs, occasionally other species | *Causes disease in sheep, goats and pigs, occasionally other species | ||
*Starts as a pyemia and localises in varius tissues, including the lung as abscessation | *Starts as a pyemia and localises in varius tissues, including the lung as abscessation | ||
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**ELISA, complement fixation and indirect haemagglutination tests for serum antibodies | **ELISA, complement fixation and indirect haemagglutination tests for serum antibodies | ||
*Treatment/control: slaughter of infected animals where exotic | *Treatment/control: slaughter of infected animals where exotic | ||
| − | *[[ | + | *[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|Pneumonia]] and arthritis are the most common presentation |
| − | + | [[Category:Respiratory_Bacterial_Infections]][[Category:Sheep]] | |
| − | + | [[Category:To_Do_-_Clinical]] | |
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Revision as of 09:44, 26 July 2010
(Pseudoglanders)
- Caused by Pseudomonas (Malleomyces) pseudomallei, Closely related to P. mallei in horses
- Causes disease in sheep, goats and pigs, occasionally other species
- Starts as a pyemia and localises in varius tissues, including the lung as abscessation
- Encapsulated abscesses contain yellow, caseous or creamy pus
- Pathogenesis:
- Infection via ingestion, inhalation or skin wounds from environment
- Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
- Strain virulence and host immunosuppression important
- Clinical infections:
- Opportunistic infection with stress and immunosuppression predisposing to disease
- Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
- Chronic, debilitating, progressive disease with long incubation period
- Many animal species susceptible
- Referred to as pseudoglanders in horses
- Diagnosis:
- Specimens: pus from abscesses, affected tissues, blood
- Fluorescent antibody technique on tissue smears
- Blood agar and MacConkey agar plates, incubated aerobically
- Colonies have musty smell
- Lactose fermentation on MacConkey
- Slide agglutination
- ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
- Treatment/control: slaughter of infected animals where exotic
- Pneumonia and arthritis are the most common presentation