Difference between revisions of "Leptospirosis - Cats and Dogs"

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==Introduction==
 
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'''Leptospirosis''' is an important zoonosis, affecting humans as well as animals. The disease can be caused by infection with a number of different serovars of the bacteria [[Leptospira|''Leptospira interrogans'']]. In general infection with a host adapted strain results in subclinical infection, intermittent shedding of the organism with the animal acting as a reservoir for infection. Infection with non host adapted strains results in clinical disease.
 
  
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''Cats do not appear to be affected by clinical disease but can become subclinically infected acting as a reservoir with intermittent shedding.''
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**Dogs and cats
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***Serovars ''canicola'' and ''icterohaemorrhagica'' cause leptospirosis in dogs, but are vaccinated against
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***Serovars ''pomona'' and ''grippotyphosa'' are becoming important
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***The host-adapted serovar ''canicolar'' causes acute renal failure in puppies; a chronic uraemic syndrome may follow
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***Incidental infections with serovar ''icterohaemorrhagica'' or ''copenhagenii'' cause renal failure
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***''L. icterohaemorrhagiae'' may cause [[Pigmentation and Calcification - Pathology#Hepatic (Toxic) Icterus|hepatic jaundice]]
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***Serovar ''bratislava'' causes abortion and infertility in dogs, which may be the maintenance host
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***Infections uncommon in cats
  
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Transmission is via urine of affected animals; the organism gains entry at mucous membranes, broken skin, bite wounds and through ingestion of infected material. The organism can remain viable for weeks in damp conditions, rodents and other mammals act as a reservoir of infection. The incubation period is 2-12 days, after which dogs become lethargic, pyrexic and anorexic. The disease often progresses with renal and hepatic involvement. The host-adapted serovar ''canicolar'' causes acute renal failure in puppies; a chronic uraemic syndrome may follow. Incidental infections with serovar ''icterohaemorrhagica'' or ''copenhagenii'' cause renal failure; ''L. icterohaemorrhagiae'' may also cause [[Icterus|hepatic jaundice]]. Serovar ''bratislava'' has been reported to cause abortion and infertility in dogs, which may be the maintenance host.
 
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Vaccination against serovars ''canicola'' and ''icterohaemorrhagica'' has greatly reduced the prevalence and incidence of disease in the UK but in some areas the disease is re-emerging as owners decide not to vaccinate due to the reduced risk. Serovars ''pomona'' and ''grippotyphosa'' are becoming important.
 
  
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==Signalment==
 
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Leptospirosis can affect dogs of any age, breed or sex. Young male, adult working dogs are at greatest risk. There are usually more cases in years with higher rainfall.
 
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==Clinical Signs==
 
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* Pyrexia
 
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* Lethargy
 
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* Anorexia
 
  
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Acute renal failure develops in 80-90% of cases; these dogs will show the typical signs of vomiting, dehydration, ureamic ulceration of the mouth and lumbar pain. In less severe renal cases polyuria and polydipsia may be the most obvious signs. Hepatic involvement results in icterus, bilirubinuria and elevations in liver enzymes.   
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*''Leptospirosis icterohaemorrhagica'' - a septicaemic disease which affects the [[Liver - Anatomy & Physiology|liver]]
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*puppies
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*Leptospirosis is an important spirochaetal group of diseases causing disease in animals and humans (zoonotic)
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*Transmission
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**via urine of affected animals
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**organisms can remain viable for weeks in damp conditions
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*method of action
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**cause anaemia via intravascular haemolysis
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=====Clinical=====
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*fever
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*dehydration
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*haemorrhaging from the mucous membranes of the body
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=====Diagnosis=====
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*dark field microscopy on fresh urine is best
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=====Gross=====
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*widespread hameorrhages
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*icterus
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*pale foci in the [[Liver - Anatomy & Physiology|liver]] (not always a constant finding)
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*subcapsular and cortical renal haemorrhages
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=====Microscopically=====
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*foci of necrosis
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*dissociation of hepatocytes form each other (similar to post mortem change)
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*substantial haemosiderin in the Kuppfer cells (from the haemolysis)
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*need to use a silver stain or immunofluorescence to demonstrate the organisms in tissues
  
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==Laboratory Tests==
 
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Diagnosis can be confirmed by culture of the organism from urine, blood or tissues. The organism can also be identified through dark field microscopy of urine or PCR carried out on blood, urine or tissues. A rising antibody titre in conjunction with suggestive clinical signs is also sufficient for diagnosis.
 
  
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The tests may reveal false negatives due to the intermittent shedding of the organism. 
 
  
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==Pathology==
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[[Category:Cat]][[Category:Dog]]
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Grossly-
 
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* Widespread haemorrhages
 
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* Icterus
 
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* Pale foci in the [[Liver - Anatomy & Physiology|liver]] (not always a constant finding)
 
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* Subcapsular and cortical renal haemorrhages
 
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<br>
 
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Microscopically-
 
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* Foci of necrosis
 
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* Dissociation of hepatocytes
 
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* Substantial haemosiderin in the Kuppfer cells
 
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* A silver stain or immunofluorescence will demonstrate the organisms in tissues
 
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==Treatment==
 
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Supportive treatment should be given in cases of renal failure and hepatic disease.
 
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'''Doxycycline''' is the antibiotic of choice for treating leptospirosis as it also targets the renal carrier phase, preventing transmission of the disease.
 
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Appropriate protective measures should be taken by those treating cases of leptospirosis due to the zoonotic potential.
 
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{{Learning
 
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|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=title%3A%28leptospir*%29+AND+%28od%3A%28cats%29+OR+od%3A%28dogs%29%29&occuring1=freetext&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&publishedstart=2000&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all&x=41&y=15 Leptospirosis in dogs (and cats) publications since 2000]
 
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|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2009/20093115248.pdf ''' Canine leptospirosis update.''' Guptill, L.; The North American Veterinary Conference, Gainesville, USA, Small animal and exotics. Proceedings of the North American Veterinary Conference, Orlando, Florida, USA, 17-21 January, 2009, 2009, pp 644-646, 22 ref.]
 
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[http://www.cabi.org/cabdirect/FullTextPDF/2007/20073119563.pdf ''' Canine leptospirosis - a persisting challenge.''' Gaschen, F. P.; The North American Veterinary Conference, Gainesville, USA, Small animal and exotics. Proceedings of the North American Veterinary Conference, Volume 21, Orlando, Florida, USA, 2007, 2007, pp 600-602]
 
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|Vetstream = [https://www.vetstream.com/felis/Content/Bug/bug00176.asp Leptospirosis]
 
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}}
 
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==References==
 
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* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
 
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* Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''
 
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{{review}}
 
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{{OpenPages}}
 
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[[Category:Liver Diseases - Cat]][[Category:Liver Diseases - Dog]]
 
 
[[Category:Hepatitis,_Bacterial]]
 
[[Category:Hepatitis,_Bacterial]]
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[[Category:Expert_Review]]
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[[Category:To_Do_-_lizzyk]]

Revision as of 16:32, 27 July 2010


 This article is still under construction.


    • Dogs and cats
      • Serovars canicola and icterohaemorrhagica cause leptospirosis in dogs, but are vaccinated against
      • Serovars pomona and grippotyphosa are becoming important
      • The host-adapted serovar canicolar causes acute renal failure in puppies; a chronic uraemic syndrome may follow
      • Incidental infections with serovar icterohaemorrhagica or copenhagenii cause renal failure
      • L. icterohaemorrhagiae may cause hepatic jaundice
      • Serovar bratislava causes abortion and infertility in dogs, which may be the maintenance host
      • Infections uncommon in cats


  • Leptospirosis icterohaemorrhagica - a septicaemic disease which affects the liver
  • puppies
  • Leptospirosis is an important spirochaetal group of diseases causing disease in animals and humans (zoonotic)
  • Transmission
    • via urine of affected animals
    • organisms can remain viable for weeks in damp conditions
  • method of action
    • cause anaemia via intravascular haemolysis
Clinical
  • fever
  • dehydration
  • haemorrhaging from the mucous membranes of the body
Diagnosis
  • dark field microscopy on fresh urine is best
Gross
  • widespread hameorrhages
  • icterus
  • pale foci in the liver (not always a constant finding)
  • subcapsular and cortical renal haemorrhages
Microscopically
  • foci of necrosis
  • dissociation of hepatocytes form each other (similar to post mortem change)
  • substantial haemosiderin in the Kuppfer cells (from the haemolysis)
  • need to use a silver stain or immunofluorescence to demonstrate the organisms in tissues
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