Difference between revisions of "Viral Pathogenesis"

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Revision as of 12:26, 30 July 2010

Viruses bind to host cells via specific receptors, partly determining which cell types become infected:

Virus Receptor Cell type infected
HIV CD4 Helper T cells
Epstein-Barr virus Complement receptor (type-2) B cells
Influenza A virus Glycophorin A Many cell types
Polio virus Polio virus receptor Neurons

Examples of pathogenesis of viruses:

  • Fifth disease: caused by parvovirus B19, characterised by 'slapped cheek' rash
  • Verruca vulgaris: caused by human papillomaviruses-1, -2 and -3
  • Cervical cancer: caused by human papillomaviruses-16 and -18
  • Acute respiratory disease: caused by adenoviruses -3, -4 and -7. Symptoms include flu-like fever, headache and chills
  • Cytomegalovirus: caused by a type of herpesvirus, CMV is the most common viral infection found in infants
  • Smallpox: caused by a type of poxvirus