Difference between revisions of "Feline Odontoclastic Resorptive Lesions"

Revision as of 09:01, 6 August 2010

Also known as:

FORLs

Description

Feline odontoclastic resorptive lesions (FORLs) are the most commonly seen dental lesions in cats. On examination, there is a loss of dental tissue on the crown or at the neck of the teeth. The crown may be completely resorbed with the remaining root covered with gingiva.

The aetiology and pathogenesis of FORLs has not yet been demonstrated but is almost certainly multifactorial. Possible hypotheses that have been suggested include, the texture of the diet, abnormal calcium regulation, hypervitaminosis A, mechanical stress, anatomical abnormalities of the teeth, viral infections and plaque bacteria and periodontal disease.

Typical Signalment

There are no sex or breed predispositions however it does become more prevalent with increasing age.

Diagnosis

Clinical Signs

Anorexia, drooling, lethargy and pain on contact with the lesions.

Oral Examination

Visual Examination will identify the lesions or inflammed gingiva that overlies the remaining root.

Lesions that are subgingival may be identified using a dental probe.

Diagnostic Imaging

Radiographic signs of FORLs include erosion of alveolar bone at the cementoenamel junction, root resorption, root ankylosis and subsequent periodontal space loss and resorption of the dental crown.

Classifying the Lesions

Classifying the lesions allows a logical treatment regime to be implemented. It can be based on the severity of the resorptive lesions.

Is a round or oval punched out lesion of the gastric mucosa ranging from 1-4 cm in diameter.

There are many disease associations including:

Disease type	Area affected
Stage 1	Enamel only
Stage 2	Enamel and dentine
Stage 3	Pulp exposure
Stage 4	Extensive structural damage
Stage 5a	Crown is resorbed but the roots are retained.
Stage 5b	Crown is intact but the root is resorbed

Pathology

Odontoclasts attack external and internal to the tooth. Initially they start at the neck/cervical region and extend into tooth root and also enter the root via the apical foramen (stage 3 lesions).

- 20%+ of cats have them

FORLs are different from caries – demineralization by bacteria fermenting CHO on the enamel.

Odontoclasts normally only active in young animals to resorb the deciduous teeth to make way for the permanent teeth – so represents abnormal activation in adults. Additionally there may also be inflammatory infiltrates into the resportive lesions.

Treatment

There are various treatment options available for the different stages of disease.

Stage 1-2
- Scale and polish
- Fluoride treatment
- Pit and fissure sealant
Stage 2
- Scale and polish
- Restoration of the tooth using glass ionomer, compomer or composite (High failure rate)
Stage 2-4
- Extraction
- Crown amputation whilst retaining root
Stage 5a
- Extraction
- Root retention
Stage 5b
- Crown amputation

References

Tutt, C., Deeprose, J. and Crossley, D. (2007) BSAVA Manual of Canine and Feline Dentistry (3rd Edition) BSAVA

Merck & Co (2008) The Merck Veterinary Manual

@@ Line 1: / Line 1: @@
-{{OpenPagesTop}}
+{{unfinished}}
-Also known as: '''''FORL — Neck lesions — Feline Tooth Resorption — Cervical Line Lesions — Dental Resorptive Lesions — Feline Caries — RL'''''
-==Introduction==
+{| cellpadding="10" cellspacing="0" border="1"
-[[File:Tooth resorption 1.jpg|200px|right|thumb|Image 1: Feline tooth resorption]]
+| Also known as:
-[[File:Tooth resorption 2.jpg|200px|right|thumb|Image 2: Feline tooth resorption -  focal hyperplastic gingival tissue covering the tooth defect]]
+| '''FORLs'''
-[[File:Tooth resorption 3.jpg|200px|right|thumb|Image 3: Feline tooth resorption - red spot on crown of the tooth]]
+|-
-[[File:Tooth resorption 4.jpg|200px|right|thumb|Image 4: Feline tooth resorption - red spot on crown of the tooth]]
+|}
-[[File:TR5.jpg|200px|right|thumb|Image 5: Feline tooth resorption - Missing/fractured teeth; site may have inflamed covering gingiva and/or bony swelling.]]
-[[File:Explorer probe and dental resorption.jpg|200px|right|thumb|Image 6: Explorer probe being used to identify tooth resorption in the 4th premolar]]
-[[File:Tooth resorption 7.jpg|200px|right|thumb|Image 7: Feline tooth resorption radiograph]]
-[[File:Cat mandibular radiograph 1.jpg|200px|right|thumb|Tooth resorption]]
-Feline tooth resorption or feline odontoclastic resorptive lesions (RL) (also referred to as cervical line lesions, neck lesions, dental resorptive lesions and feline caries) affect more than one third of adult domestic cats and are the second most common [[:Category:Oral Diseases - Cat|oral problem seen in cats]] (after [[periodontitis]]), with prevalence increasing with age (image 1).
-On examination, there is a loss of dental tissue on the [[Tooth - Anatomy & Physiology#Crown|crown]] or at the neck of the [[:Category:Teeth - Anatomy & Physiology|tooth]]. The crown may be completely resorbed with the remaining root covered with [[Gingiva|gingiva]].
+==Description==
-==Aetiology and Pathogenesis==
+Feline odontoclastic resorptive lesions (FORLs) are the most commonly seen dental lesions in cats. On examination, there is a loss of dental tissue on the [[Crown - Anatomy & Physiology|crown]] or at the neck of the teeth. The crown may be completely resorbed with the remaining root covered with [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|gingiva]].
-The aetiology and pathogenesis of FORLs has not yet been demonstrated but is almost certainly multifactorial. Possible hypotheses that have been suggested include, the texture of the diet, abnormal calcium regulation, [[Hypervitaminosis A|hypervitaminosis A]], mechanical stress, [[Developmental Dental Conditions|anatomical abnormalities of the teeth]], [[:Category:Cat Viruses|viral infections]] and plaque bacteria and [[Periodontal Disease|periodontal disease]].
-Hard tissues are protected from resorption by their surface layers of blast cells. It appears that as long as these layers are intact, resorption cannot occur. However bone, [[dentine]] and [[cementum]] are mesenchymal, mineralized tissues composed mainly of collagen and hydroxyapatite, and they differ markedly in their susceptibility to resorption.
-Two mechanisms are involved in resorption of hard tissue:
-# The trigger
-# A reason for the resorption to continue
-The trigger mechanism in root resorption is a root surface detached from its protective blast cell layer. For the resorption to continue, a stimulus is required, e.g. infection or a continuous mechanical force.
-Root resorption always starts at a surface, and is termed '''internal if emanating from the root canal wall''' and as '''external if emanating from the root surface'''. Internal resorption is rare in permanent teeth. Histological examination reveals resorption of the internal aspect of the root by multinucleated [[Giant Cells|giant cells]] adjacent to granulation tissue in the pulp. There are different theories regarding the origin of the pulpal granulation tissue involved in internal resorption. The most logical explanation is that it is pulp tissue that is inflamed because of an infected coronal pulp space. In addition to the requirement of the presence of granulation tissue, root resorption takes place only if the [[odontoblast]] layer and predentine are lost or altered. Traditionally, a pink tooth has been thought pathognomonic of internal root resorption; the pink colour is caused by granulation tissue in the coronal dentine undermining the crown [[enamel]]. However, a pink tooth can also be a feature of a specific type of external root resorption, namely peripheral inflammatory external root resorption (detailed later), which must be ruled out before a diagnosis of internal root resorption is made. A pink tooth can also be due to pulpal haemorrhage. There are different forms of external root resorption described in man. The underlying mechanism is understood for some of these, whereas other forms are still unexplained and therefore termed idiopathic. A classification system for external root resorptions that have a known mechanism has been proposed in man and is as follows:
-# Surface resorption
-# Replacement resorption associated with ankylosis
-# Inflammatory resorption
-This classification system works for external root resorption in cats and dogs as well.
-'''SURFACE RESORPTION''' - is initiated subsequent to injury of the [[cementoblast]] layer. It is thought that minor traumas caused by unintentional biting on hard objects, bruxism, etc. can cause localized damage to the [[Tooth - Anatomy & Physiology#Periodontal Ligament|periodontal ligament]] and trigger this type of resorption. The process is self-limiting and reversible.
-'''REPLACEMENT RESORPTION''' - results in replacement of the dental hard tissue by [[Bones - Anatomy & Physiology|bone]]. When a surface resorption stops, cells from the periodontal ligament will proliferate and populate the resorbed area. Cells from the nearby bone may then arrive first and establish themselves on the resorbed surface. Bone will thus be formed directly upon the dental hard tissue. This results in fusion between bone and tooth, i.e. ankylosis. When the resorptive process is over, the [[osteoblasts]] will form bone in the resorbed area. In this way the dental tissues will gradually be replaced by bone.
-'''INFLAMMATORY RESORPTION''' - In addition to apical root resorption caused by apical [[periodontitis]] as a consequence of pulpal necrosis, there are two main forms of external resorption associated with inflammation in the periodontal tissues, namely:
+The aetiology and pathogenesis of FORLs has not yet been demonstrated but is almost certainly multifactorial. Possible hypotheses that have been suggested include, the texture of the diet, abnormal calcium regulation, hypervitaminosis A, mechanical stress, anatomical abnormalities of the teeth, viral infections and plaque bacteria and periodontal disease.
-# Peripheral inflammatory root resorption (PIRR)
-# External inflammatory root resorption (EIRR).
-Both forms are triggered by destruction of the cementoblasts. In PIRR, the osteoclast-activating factors, which perpetuate the resorptive process, are provided by an inflammatory lesion in the adjacent periodontal tissues. EIRR, on the other hand, receives its stimulus for continued resorption from an infected necrotic pulp. In other words, the common factor for these two types of resorption is inflammation in the adjacent tissues.
-Tooth resorption in cats accounts for a large proportion of the dental case load seen in general veterinary practice. Most studies have shown an increased incidence with increasing age. The lesions have also been shown to occur in both feral and wild cats, and in other species, e.g. man, dog and chinchilla.
-It is likely that the lesions are either peripheral inflammatory root resorption (triggered by inflammation of periodontal tissues) or replacement resorption (idiopathic).
 ==Typical Signalment==
-There are no sex or breed predispositions, however, it does become more prevalent with age.
+There are no sex or breed predispositions however it does become more prevalent with increasing age.
-==Clinical Signs==
-Anorexia, drooling, lethargy and pain on contact with the lesions.
-Clinically, they commonly present as a cavity at the cemento-enamel junction of the tooth. However, studies which included radiography have demonstrated that the resorption can occur anywhere on the root surfaces, i.e. not necessarily at the cemento-enamel junction.
-All types of teeth in the feline dentition may be affected by tooth resorption but molar and premolar teeth are more frequently affected than canine and incisor teeth. Also, the buccal/labial surfaces tend to be more likely to be affected compared to the lingual/palatal aspect of the tooth. The lesions are often bilaterally symmetrical.
 ==Diagnosis==
-The lesions can be detected by means of a combination of visual inspection, tactile examination with a [[Dental Explorer|dental explorer]] and [[Intra-Oral Radiography - Small Animal|radiography]].
+===Clinical Signs===
+Anorexia, drooling, lethargy and pain on contact with the lesions.
-====[[Oral Examination - Small Animal|Oral Examination]]====
+===Oral Examination===
-Visual inspection and tactile examination with a dental explorer will only identify end-stage lesions, i.e. when the process involves the crown and has resulted in an obvious cavity.
+Visual Examination will identify the lesions or inflammed gingiva that overlies the remaining root.
-Signs on visual inspection which are consistent with RLs:
+Lesions that are subgingival may be identified using a dental probe.
-* Focal hyperplastic gingival tissue covering the tooth defect. This gingival covering is usually, but not always, inflamed (image 2).
-* Red spot on crown of the tooth as seen in the images (images 3 and 4).
-* Missing/fractured teeth; site may have inflamed covering gingiva and/or bony swelling (image 5).
-* Root fragments
-====[[Intra-Oral Radiography - Small Animal|Intra-Oral Radiography]]====
+===Diagnostic Imaging===
-A definitive diagnosis can only be made after an examination and intra-oral radiography with the cat [[Oral Examination Under General Anaesthesia|under general anaesthesia]]. The lesion can be felt as a concavity using a sharp explorer probe (image 6). Lesions are often only detected once the calculus has been removed.
+Radiographic signs of FORLs include erosion of alveolar bone at the cementoenamel junction, root resorption, root ankylosis and subsequent periodontal space loss and resorption of the dental crown.
-Visualisation is aided by drying the teeth using the air stream from a dental air-water syringe. With normal teeth, the marginal gingiva will lift away from the tooth when the air is directed at the base of the [[Tooth - Anatomy & Physiology#Crown|crown]], but with RLs, the soft tissue seems “stuck” to the underlying tooth. General anaesthesia is imperative as examination of these lesions in a conscious cat is painful.
+===Classifying the Lesions===
+Classifying the lesions allows a logical treatment regime to be implemented. It can be based on the severity of the resorptive lesions.
-Radiography will identify lesions that are localized to the root surfaces within the [[Tooth - Anatomy & Physiology#Alveolar Bone|alveolar bone]], which cannot be detected by clinical methods. Radiography is also required to confirm the diagnosis and to assess the extent and type of the lesion. Radiographs often reveal a lesion that is more advanced than originally suspected from the clinical examination (image 7).
+Is a round or oval punched out lesion of the gastric mucosa ranging from 1-4 cm in diameter.
-[[Radiographic Interpretation of Tooth Resorption - Small Animal|Radiographic Features of RLs]]: <br>
+There are many disease associations including:
-a) Loss of integrity of the periodontal ligament space. <br>
-b) Loss of the lamina dura.<br>
-c) Irregularities on the root surface.<br>
-d) Diffuse decrease in radiodensity of the entire root compared with adjacent roots.<br>
-e) Radiolucent areas within the root dentine often extending into the crown dentine.<br>
-f) Replacement of root substance by bone-like tissue. <br>
-g) Resorbing roots present with clinically missing crown. <br>
-For more information see [[Radiographic Interpretation of Tooth Resorption - Small Animal|radiographic interpretation of tooth resorption]].
+{| style="width:100%; height:200px" border="1"
-====Classifying the Lesions====
-Classification of tooth resorption :
-[http://www.avdc.org/nomenclature.html#resorption American Veterinary Dental College classification pictures]
-<center>
-{| style="width:80%; cellspacing="2" border="1"
 ! '''Disease type'''
@@ Line 104: / Line 47: @@
 |-
-|'''Stage 1 (TR 1)'''
+|'''Stage 1'''
-|Mild dental hard tissue loss ([[cementum]] or cementum and [[enamel]]).
+|[[Enamel - Anatomy & Physiology|Enamel]] only
+|-
+|'''Stage 2'''
+|Enamel and dentine
 |-
-|'''Stage 2 (TR 2)'''
+|'''Stage 3'''
-|Moderate dental hard tissue loss (cementum or cementum and enamel with loss of dentin that does not extend to the pulp cavity).
+|Pulp exposure
 |-
-|'''Stage 3 (TR 3)'''
+|'''Stage 4'''
-|Deep dental hard tissue loss (cementum or cementum and enamel with loss of dentin that extends to the pulp cavity); most of the tooth retains its integrity.
+|Extensive structural damage
 |-
-|'''Stage 4 (TR 4)'''
+|'''Stage 5a'''
-|Extensive dental hard tissue loss (cementum or cementum and enamel with loss of dentin that extends to the pulp cavity); most of the tooth has lost its integrity. <br>
+|[[Crown - Anatomy & Physiology|Crown]] is resorbed but the roots are retained.
-'''TR4a''' - Crown and root are equally affected. Extensive dental hard tissue loss (cementum or cementum and enamel with loss of dentin that extends to the pulp cavity); most of the tooth has lost its integrity.<br>
-'''TR4b''' - Crown is more severely affected than the root. Extensive dental hard tissue loss (cementum or cementum and enamel with loss of dentin that extends to the pulp cavity); most of the tooth has lost its integrity.<br>
-'''TR4c''' - Root is more severely affected than the crown.
 |-
-|'''Stage 5 (TR 5)'''
+|'''Stage 5b'''
-|Remnants of dental hard tissue are visible only as irregular radiopacities, and gingival covering is complete.
+|Crown is intact but the root is resorbed
 |}
-</center>
-==Treatment==
+==Pathology==
+Odontoclasts attack external and internal to the [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|tooth]]. Initially they start at the neck/cervical region and extend into [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|tooth]] [[Root - Anatomy & Physiology|root]] and also enter the root via the apical foramen (stage 3 lesions).
+**20%+ of cats have them
+FORLs are different from caries – demineralization by bacteria fermenting CHO on the [[Enamel - Anatomy & Physiology|enamel]].
-Currently, the suggested methods for management of odontoclastic resorptive lesions are:
-# Conservative management
+Odontoclasts normally only active in young animals to resorb the [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology#Temporary Tooth|deciduous teeth]] to make way for the [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology#Permanent Tooth|permanent teeth]] – so represents abnormal activation in adults.
-# Tooth extraction
+Additionally there may also be inflammatory infiltrates into the resportive lesions.
-# Coronal amputation
-Historically, restoration of the tooth surface has been recommended for the treatment of accessible lesions that extend into the dentine and do not involve pulp tissue. However, several studies have shown that tooth resorption continues and the restorations are lost. Consequently, the use of restoration of odontoclastic lesions as a major treatment technique cannot be recommended.
+==Treatment==
-====Conservative Management====
+There are various treatment options available for the different stages of disease.
-This consists of monitoring the lesions clinically and radiographically. This approach is recommended for lesions that are not evident on clinical examination, i.e. only seen radiographically, and there is no evidence of discomfort or pain. In general practice, most lesions are only diagnosed when pathology is extensive and conservative management is rarely an option.
-In most cases, extraction or coronal amputation of an affected tooth is indicated. Preoperative radiographs are mandatory to allow selection of the appropriate treatment option.
+*'''Stage 1-2'''
+**Scale and polish
-====Extraction====
+**Fluoride treatment
-Teeth with resorption are notoriously difficult to extract, as the root is resorbing and being replaced by bone-like tissue. Moreover, there are areas of ankylosis, i.e. fusion of bone and tooth substance, along the root surface.
+**Pit and fissure sealant
+*'''Stage 2'''
-Teeth affected by resorption can be extracted using a closed technique, but an open technique is usually less traumatic to the tissues and easier to perform. The teeth are often prone to fracture so an open technique allows good access to any root fragments remaining.
+**Scale and polish
+**Restoration of the tooth using glass ionomer, compomer or composite (High failure rate)
-====Coronal Amputation====
+*'''Stage 2-4'''
-The indications for, and outcome of, coronal amputation have been well documented and the procedure is recommended for selected cases, but needs radiographic monitoring at regular intervals postoperatively to ensure that the root is resorbing and that healing is uneventful. In brief, the technique involves raising a gingival flap to expose the margin of the alveolar bone. The crown of the affected tooth is amputated using a small round bur. A small amount of root tissue is also removed with the bur, just enough to ensure that the intentionally retained root(s) is (are) apical to the alveolar margin. The gingival flap is replaced and sutured in place. This technique is only appropriate for teeth that do not have any radiographic evidence of [[Endodontic Conditions|endodontic disease]] (ie. periapical inflammation) or [[periodontitis]], and teeth in cats with gingivostomatitis should be removed entirely.
+**Extraction
+**[[Crown - Anatomy & Physiology|Crown]] amputation whilst retaining root
+*'''Stage 5a'''
+**Extraction
-{{Learning
+**Root retention
-|literature search = [http://www.cabdirect.org/search.html?q=%28title%3A%28%22neck+lesions%22%29+OR+title%3A%28FORL%29+OR+title%3A%28%22Odontoclastic+Resorptive+Lesions%22%29%29+AND+od%3A%28cats%29 Feline odontoclastic resorptive lesions publications]
+*'''Stage 5b'''
-|Vetstream = [https://www.vetstream.com/felis/Content/Disease/dis60094.asp Resorption lesions]
+**[[Crown - Anatomy & Physiology|Crown]] amputation
-}}
 ==References==
-Tutt, C., Deeprose, J. and Crossley, D. (2007) '''BSAVA Manual of Canine and Feline Dentistry (3rd Edition)''' ''BSAVA''
-Merck & Co (2008) '''The Merck Veterinary Manual''' ''Merial''
-{{Lisa Milella reviewed
-|date = 22 October 2014}}
-{{Waltham}}
-{{OpenPages}}
+*Tutt, C., Deeprose, J. and Crossley, D. (2007) '''BSAVA Manual of Canine and Feline Dentistry (3rd Edition)''' ''BSAVA''
-[[Category:Teeth_-_Inflammatory_Pathology]][[Category:Oral Diseases - Cat]]
+*Merck & Co (2008) '''The Merck Veterinary Manual'''
-[[Category:Dental Conditions]]
+[[Category:Teeth_-_Inflammatory_Pathology]][[Category:Cat]]
-[[Category:Lisa Milella reviewed]]
+[[Category:To_Do_-_Caz]]
-[[Category:Waltham reviewed]]