Difference between revisions of "Glanders"
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| − | + | ==Description== | |
| − | + | '''Glanders''' is a contagious disease caused by [[Burkholderia mallei|''Burkholderia (Pseudomonas) mallei'']]. It exists in '''acute''' and '''chronic''' forms. Animals are infected by ingestion of contaminated feed or water, inhalation or via open wounds. The organism invades mucosa and desseminates to other tissue via the lymphatics. | |
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| − | '''Glanders''' is a contagious disease caused by | ||
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Three forms of the condition have been described; animals will show signs of one or more forms. | Three forms of the condition have been described; animals will show signs of one or more forms. | ||
| − | + | * Pulmonary form: | |
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Small calcified or caseous nodules develop in the lungs, the surrounding tissue becomes inflamed and consolidated. The resulting pneumonia causes respiratory distress and coughing. The nodules frequently degenerate and release their contents into the bronchioles which results in spread of the infection into the upper airways. | Small calcified or caseous nodules develop in the lungs, the surrounding tissue becomes inflamed and consolidated. The resulting pneumonia causes respiratory distress and coughing. The nodules frequently degenerate and release their contents into the bronchioles which results in spread of the infection into the upper airways. | ||
| − | + | * Nasal form: | |
| + | Nodules form on the nasal mucosa, nasal septum and nasal turbinates. These break down to become ulcerative with raised irregular borders, the lesions may heal to form chracteristic star shaped scars. A thick mucopurulent discharge is seen at the nostrils. The local lymph nodes are enlarged and as the disease progresses, they become firm and adhere to underlyinig tissues. | ||
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| + | * Cutaneous form (Farcy): | ||
| + | Nodules form overlying lymph vessles, especially of the extremities and limbs. These nodules rupture to release thick pus which is highly infectious. | ||
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Carnivores can also be infected by ingestion of infected carcasses. | Carnivores can also be infected by ingestion of infected carcasses. | ||
| − | The | + | The diease is '''zoonotic''', humans are infected by inoculation through a wound and mortality is high. |
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==Signalment== | ==Signalment== | ||
Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form. | Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form. | ||
| − | The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease. Animals imported from areas at high risk of the disease must be blood tested before entry into the UK is | + | The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease. Animals imported from areas at high risk of the disease must be blood tested before entry into the UK is permited. Distribution is limited to parts of SE Asia, The Middle East, India, North Africa, China and Mongolia. |
==Diagnosis== | ==Diagnosis== | ||
| − | + | Clinical signs may be sufficient to diagnose the condition, however they do not develop until the disease is advanced, therefore specific tests are indicated in suspected cases to aid prompt diagnosis. | |
===Clinical Signs=== | ===Clinical Signs=== | ||
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====Acute==== | ====Acute==== | ||
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====Chronic==== | ====Chronic==== | ||
* Nodular, ulcerative nasal lesions | * Nodular, ulcerative nasal lesions | ||
| − | * Subcutaneous nodules which | + | * Subcutaneous nodules which rupure and discharge exudate |
* Enlarged lymph nodes | * Enlarged lymph nodes | ||
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Animals are debilitated and show clinical signs for several months, the disease may be fatal or the animal may appear to recover but it will act as a carrier and source of infection for spread of the disease. | Animals are debilitated and show clinical signs for several months, the disease may be fatal or the animal may appear to recover but it will act as a carrier and source of infection for spread of the disease. | ||
| − | ===Clinical | + | ===Clinical tests=== |
| − | The | + | The Mallein test is used most frquently to diagnose the condition, a fraction of the causative organism is injected intradermally into the eyelid or applied as eyedrops, a positive result is seen as local swelling and discharge 1-2 days post testing. |
===Laboratory Tests=== | ===Laboratory Tests=== | ||
| − | Other diagnostic tests include an | + | Other diagnostic tests include an Elisa, complement fixation and culture of the orgamism from exudative lesions. |
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==Treatment== | ==Treatment== | ||
There is no vaccine available. Prevention and control focuses on prompt detection and slaughter of infected animals and complete quarantine and disinfection of the affected premises. | There is no vaccine available. Prevention and control focuses on prompt detection and slaughter of infected animals and complete quarantine and disinfection of the affected premises. | ||
==Prognosis== | ==Prognosis== | ||
| − | Prognosis is poor, the | + | Prognosis is poor, the diease is usually fatal. Animals which survive should be slaughtered to prevent spread of the disease. |
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==References== | ==References== | ||
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* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial'' | * Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial'' | ||
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[[Category:Respiratory_Bacterial_Infections]] | [[Category:Respiratory_Bacterial_Infections]] | ||
[[Category:Zoonoses]] | [[Category:Zoonoses]] | ||
| − | [[Category: | + | [[Category:To_Do_-_lizzyk]] |
| + | [[Category:To_Do_-_Review]] | ||
| + | [[Category:Respiratory_Disorders_-_Horse]] | ||
Revision as of 11:48, 9 August 2010
 |
This article is still under construction. |
Description
Glanders is a contagious disease caused by Burkholderia (Pseudomonas) mallei. It exists in acute and chronic forms. Animals are infected by ingestion of contaminated feed or water, inhalation or via open wounds. The organism invades mucosa and desseminates to other tissue via the lymphatics.
Three forms of the condition have been described; animals will show signs of one or more forms.
- Pulmonary form:
Small calcified or caseous nodules develop in the lungs, the surrounding tissue becomes inflamed and consolidated. The resulting pneumonia causes respiratory distress and coughing. The nodules frequently degenerate and release their contents into the bronchioles which results in spread of the infection into the upper airways.
- Nasal form:
Nodules form on the nasal mucosa, nasal septum and nasal turbinates. These break down to become ulcerative with raised irregular borders, the lesions may heal to form chracteristic star shaped scars. A thick mucopurulent discharge is seen at the nostrils. The local lymph nodes are enlarged and as the disease progresses, they become firm and adhere to underlyinig tissues.
- Cutaneous form (Farcy):
Nodules form overlying lymph vessles, especially of the extremities and limbs. These nodules rupture to release thick pus which is highly infectious.
Carnivores can also be infected by ingestion of infected carcasses. The diease is zoonotic, humans are infected by inoculation through a wound and mortality is high.
Signalment
Equidae are most commonly affected, horses tend to get the chronic form and mules and donkeys the acute form. The disease was once widespread in the UK but was eradicated in 1928 and is now a Notifiable disease. Animals imported from areas at high risk of the disease must be blood tested before entry into the UK is permited. Distribution is limited to parts of SE Asia, The Middle East, India, North Africa, China and Mongolia.
Diagnosis
Clinical signs may be sufficient to diagnose the condition, however they do not develop until the disease is advanced, therefore specific tests are indicated in suspected cases to aid prompt diagnosis.
Clinical Signs
Acute
- Pyrexia
- Mucopurulent nasal discharge
- Ulceration of nasal mucosa
- Coughing
- Death
Affected animals are septicaemic and die within a few days.
Chronic
- Nodular, ulcerative nasal lesions
- Subcutaneous nodules which rupure and discharge exudate
- Enlarged lymph nodes
Animals are debilitated and show clinical signs for several months, the disease may be fatal or the animal may appear to recover but it will act as a carrier and source of infection for spread of the disease.
Clinical tests
The Mallein test is used most frquently to diagnose the condition, a fraction of the causative organism is injected intradermally into the eyelid or applied as eyedrops, a positive result is seen as local swelling and discharge 1-2 days post testing.
Laboratory Tests
Other diagnostic tests include an Elisa, complement fixation and culture of the orgamism from exudative lesions.
Treatment
There is no vaccine available. Prevention and control focuses on prompt detection and slaughter of infected animals and complete quarantine and disinfection of the affected premises.
Prognosis
Prognosis is poor, the diease is usually fatal. Animals which survive should be slaughtered to prevent spread of the disease.
References
- http://www.defra.gov.uk/foodfarm/farmanimal/diseases/atoz/glanders/
- Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial