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| | [[Vascular Fragility]] | | [[Vascular Fragility]] |
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| | + | [[Platelet Abnormalities]] |
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| − | ===Disease associated with platelet abnormalities===
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| − |
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| − | ====Primary Thrombocytopenic Disease====
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| − |
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| − | * The aetiology of primary thrombocytopenic disease is often uncertain.
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| − | ** It is therefore also known as idiopathic thrombocytopenia.
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| − | ** The cause may be automimmune.
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| − | * Although the [[Bone Marrow - Anatomy & Physiology|bone marrow]] contains adequate normal megakaryocytes, there is a reduced peripheral blood thrombocyte count.
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| − | * Usually seen in young animals.
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| − |
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| − | ====Secondary Thrombocytopenic Disease====
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| − |
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| − | * Secondary thrombocyopaenic disease is fairly common in adult and older domestic animals.
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| − | * Associated with diseases which cause [[Bone Marrow - Anatomy & Physiology|bone marrow]] depression.
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| − | * The [[Bone Marrow - Anatomy & Physiology|bone marrow]] is depleted or devoid of megakaryocytes, and there is a nil or markedly reduced peripheral blood thrombocyte count.
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| − | * Secondary thrombocyopenic disease is seen in the following conditions:
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| − | *# Severe viral infections.
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| − | *#* For examople, ICH, feline panleucopenia, [[Bovine Viral Diarrhoea Virus|mucosal disease]], [[Classical Swine Fever|swine fever]].
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| − | *# Severe protozoal infections.
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| − | *#* For example, in the UK, Haemobartonella may be a cause.
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| − | *# Plant intoxications.
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| − | *#* For example, bracken, kale, or ragwort poisoning.
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| − | *# Drug-induced conditions.
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| − | *#* High doses of oestrogens and salicylate.
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| − | *#* Prolonged use of phenyl butazone.
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| − | *# [[Bone Marrow - Anatomy & Physiology|bone marrow]] neoplasia.
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| − | *#* For example, lymphosarcoma or myeloid leukaemia.
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| − | *# Radiation.
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| − | *#* May cause damage to the [[Bone Marrow - Anatomy & Physiology|bone marrow]] if it is severe and generalised.
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| − | *# Other miscellaneous causes.
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| − | *#* Severe bacterial infections.
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| − | *#** For example, [[:Category:Staphylococcus species|''Staphylococci'']], and those Gram -ve bacteria producing endotoxins (e.g. [[:Category:Pseudomonas and Burkholderia species|''Pseudomonas'']] or [[Salmonella|''Salmonella'']] spp.).
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| − | *#* [[Liver - Anatomy & Physiology|Liver]] disease.
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| − |
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| − | ====Thrombocytopathia====
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| − |
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| − | * A rare inherited condition.
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| − | * Recorded in the dog.
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| − | * Characterised by defective thrombocyte formation.
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| − | ** Poor adhesiveness.
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| − | ** Poor aggregations.
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| − | ** Poor platelet factor release.
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| | ===Diseases associated with coagulation factor defects=== | | ===Diseases associated with coagulation factor defects=== |