Difference between revisions of "Rheumatoid Arthritis"
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(Created page with "right|thumb|150px|Rheumatoid Arthritis-Brian Catchpole RVC 2008 '''Pathogenesis:''' * [[Type IV Hypersensitivity - Wi...") |
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'''Pathogenesis:''' | '''Pathogenesis:''' | ||
| − | * [[Type IV Hypersensitivity|Type IV hypersensitivity]]: CD4 Th-1 cell mediated. | + | * [[Type IV Hypersensitivity - WikiBlood|Type IV hypersensitivity]]: CD4 Th-1 cell mediated. |
* Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction. | * Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction. | ||
| − | + | [[Category:Cell Mediated Autoimmune Diseases]][[Category:To Do - Blood]] | |
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| − | [[Category:Cell Mediated Autoimmune Diseases | ||
Revision as of 15:00, 11 August 2010
Pathogenesis:
- Type IV hypersensitivity: CD4 Th-1 cell mediated.
- Macrophages phagocytose self antigens and can present peptides on their MHC Class II molecules. The autoreactive TH-1 cells release IFN-gamma which activates macrophages to release prostaglandins, MMP enzymes and TNF-alpha (pro-inflammatory mediator), see diagram. These cytokines cause inflammation and tissue destruction.