Difference between revisions of "Lymphopenia"

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* Lymphopenia is a redcution in the numbers of lymphocytes in the blood.
  
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==Introduction==
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* Occurs in:
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Lymphopenia is a reduction in the numbers of lymphocytes in the blood.  This phenomenon is most commonly associated with stress (as part of the '''stress leucogram''') or with viral infection.  Causes include:
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** Viruses that attack the lymphoid system.
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*[[Stress Leucogram|Stress leucogram]], characterised by '''[[Neutrophilia|neutrophilia]]''', '''[[Monocytosis|monocytosis]]''', '''[[Eosinopenia|eosinopenia]]''' and '''[[Lymphopenia|lymphopenia]]'''.  A similar pattern may occur with hyperadrenocorticism (Cushing’s disease) or exogenous corticosteroid therapy as these hormones selectively suppress lymphocytic activity and the inflammatory response in general.
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*** For example:
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*Viral infection with [[Canine Distemper Virus|canine distemper]], [[Infectious Canine Hepatitis|Infectious canine hepatitis]], [[Feline infectious enteritis|feline infectious enteritis]] or [[Bovine Viral Diarrhoea|bovine viral diarrhoea]] (BVD)
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**** [[Paramyxoviridae#Canine Distemper Virus (CDV)|Canine Distemper]]
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*Bone marrow suppression caused by '''chemotherapy''' or '''radiotherapy'''.  Since neutrophils have a much shorter circulating half life, they are the first cell line to fall with any insult to the bone marrow but lymphopenia may occur as part of a more severe pancytopenia.
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**** Infectious Canine Hepatitis
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*Inherited or acquired immunodeficiency syndromes, including '''[[Equine Severe Combined Immune Deficiency|SCID]]''' (Severe Combined Immunodeficiency Syndrome) in Arab foals and [[Feline Immunodeficiency Virus|'''feline immunodeficiency virus''']] infection.
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**** Feline Infectious Enteritis
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*Leakage of lymphatic fluid may result in loss of lymphocytes, as occurs with '''[[Lymphangiectasia|lymphangiectasia]]''' or '''[[Chylous Effusion|chylothorax]]'''.
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**** Bovine Virus Diarrhoea.
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** Irradiation
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** Corticosteroid therapy.
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*** Selectively suppresses lymphocytic activity, and the inflammatory response in general.
  
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{{Learning
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*** Other immunosuppressive drugs may act in a similar way.
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|literature search = [http://www.cabdirect.org/search.html?it=any&q2=lymphopaenia&q1=lymphopenia&calendarInput=yyyy-mm-dd&occuring1=title&show=all&rowId=1&rowId=2&rowId=3&options1=AND&options2=OR&options3=AND&occuring3=freetext&occuring2=title&publishedend=yyyy&la=any&publishedstart=yyyy&fq=sc%3A%22ve%22&y=6&x=40 Publications with 'lymphopenia' in their title]
 
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[[Category:Haematology Changes]][[Category:To Do - James]]
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{{review}}
 
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==Webinars==
 
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<rss max="10" highlight="none">https://www.thewebinarvet.com/clinical-pathology/webinars/feed</rss>
 
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[[Category:Haematology Changes]][[Category:Expert Review]][[Category:Bullet Points]]
 

Revision as of 10:42, 20 August 2010

  • Lymphopenia is a redcution in the numbers of lymphocytes in the blood.
  • Occurs in:
    • Viruses that attack the lymphoid system.
      • For example:
        • Canine Distemper
        • Infectious Canine Hepatitis
        • Feline Infectious Enteritis
        • Bovine Virus Diarrhoea.
    • Irradiation
    • Corticosteroid therapy.
      • Selectively suppresses lymphocytic activity, and the inflammatory response in general.
      • Other immunosuppressive drugs may act in a similar way.
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