Difference between revisions of "Urticaria"
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| − | Urticaria is a condition of the skin characterised by the development of multiple flat-topped, oedematous swellings (wheals) | + | ==Description== |
| + | Urticaria is a condition of the skin characterised by the development of multiple flat-topped, oedematous swellings (wheals) that dent or 'pit' with digital pressure. Episodes may be acute, chronic or recurrent. The condition occurs in all domestic animals but most commonly in the horse. | ||
==Pathogenesis== | ==Pathogenesis== | ||
| − | The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. | + | The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. The condition may occur due to exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur as a result of exposure to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens. |
==Signalment== | ==Signalment== | ||
Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs appear to be more commonly affected than other breeds. | Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs appear to be more commonly affected than other breeds. | ||
| − | ==History and | + | ==History and clinical signs== |
| − | Multiple wheals are often observed and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to | + | Multiple wheals are often observed and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. Dermatographism is a specific pressure-induced type of urticaria in which wheals form in reponse to exogenous pressure, commonly these are observed in the saddle area of the horse. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved. Pruritus may or may not be present and the lesions usually disappear rapidly. |
| − | ==Diagnosis and | + | ==Diagnosis and treatment== |
| − | Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to suspicion of the condition. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication | + | Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of the condition. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause. |
| − | Acute urticaria often resolves spontaneouly without requiring treatment | + | Acute urticaria often resolves spontaneouly without requiring treatment. Dexamethasone given once at a dose of 0.1 mg/kg IM usually results in resolution of clinical signs within 24 hours. Recurrent cases may require further investigation in order to determine the underlying cause. This may include further investigation of the animal's history and response to withdrawal of drugs or topical products. If no underlying cause is found, an investigation for allergies is indicated and may include intradermal allergy testing, insect control trials and an elimination (novel protein) diet. Biopsy of lesions is generally unrewarding but may reveal a mild to moderate perivascular to interstitial dermatitis. Antihistamines such as Hydroxyzine may be useful in the management of chronic urticaria but are ineffective in treating acute urticaria. Acupuncture has been reported to be effective in one horse. |
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| − | Recurrent cases may require further investigation in order to determine the underlying cause. This may include further | ||
==Prognosis== | ==Prognosis== | ||
| − | The prognosis with urticaria is | + | The prognosis with urticaria is generally favourable because general health is not usually affected. Recurrent con |
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==References== | ==References== | ||
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*Rose, R. J., Hodgson, D. R. (2000) '''Manual of Equine Practice''' ''Elsevier Health Sciences'' | *Rose, R. J., Hodgson, D. R. (2000) '''Manual of Equine Practice''' ''Elsevier Health Sciences'' | ||
*Scott, D. W., Miller, W. H. (2003) '''Equine Dermatology''' ''Elsevier Health Sciences'' | *Scott, D. W., Miller, W. H. (2003) '''Equine Dermatology''' ''Elsevier Health Sciences'' | ||
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[[Category:Allergic Skin Diseases]] | [[Category:Allergic Skin Diseases]] | ||
| − | [[Category: | + | [[Category:To Do - Blood]][[Category:To Do - SophieIgnarski]] |
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Revision as of 18:18, 19 September 2010
 |
This article is still under construction. |
Description
Urticaria is a condition of the skin characterised by the development of multiple flat-topped, oedematous swellings (wheals) that dent or 'pit' with digital pressure. Episodes may be acute, chronic or recurrent. The condition occurs in all domestic animals but most commonly in the horse.
Pathogenesis
The aetiopathogenesis of urticaria is complex and many causes have been suggested. The basic pathogenesis is thought to be due to degranulation of mast cells and basophils leading to the release of inflammatory mediators and an increase in vascular permeability. The condition may occur due to exogenous or endogenous hypersensitivity reactions. Exogenous urticaria may occur as a result of exposure to chemicals, medication and insect bites or stings. Endogenous urticaria occurs due to inhalation of allergens.
Signalment
Horses between 1 and 10 years of age are most prone to developing the condition. There is no sex predilection but Thoroughbreds and Arabs appear to be more commonly affected than other breeds.
History and clinical signs
Multiple wheals are often observed and occur within a few minutes or hours of exposure to the causative agent. A history of recurrence or repeated episodes is often reported. Affected areas can vary from small, localised lesions up to 3cm in diameter, to extensive generalised areas involving large areas of skin. Lesions can occur on any part of the body but usually develop on the back, legs, flanks, neck and eyelids. Dermatographism is a specific pressure-induced type of urticaria in which wheals form in reponse to exogenous pressure, commonly these are observed in the saddle area of the horse. In severe cases the mucous membranes of the nose, mouth, anus and vulva may be involved. Pruritus may or may not be present and the lesions usually disappear rapidly.
Diagnosis and treatment
Because of the numerous underlying causes of urticaria, definitive diagnosis may be difficult. Historical and clinical findings may lead to the suspicion of the condition. The localisation of lesions (e.g. site of contact with saddle or insect repellent) or history of medication of exposure to chemicals may help to determine an underlying cause.
Acute urticaria often resolves spontaneouly without requiring treatment. Dexamethasone given once at a dose of 0.1 mg/kg IM usually results in resolution of clinical signs within 24 hours. Recurrent cases may require further investigation in order to determine the underlying cause. This may include further investigation of the animal's history and response to withdrawal of drugs or topical products. If no underlying cause is found, an investigation for allergies is indicated and may include intradermal allergy testing, insect control trials and an elimination (novel protein) diet. Biopsy of lesions is generally unrewarding but may reveal a mild to moderate perivascular to interstitial dermatitis. Antihistamines such as Hydroxyzine may be useful in the management of chronic urticaria but are ineffective in treating acute urticaria. Acupuncture has been reported to be effective in one horse.
Prognosis
The prognosis with urticaria is generally favourable because general health is not usually affected. Recurrent con
References
- Mair, T. S., Love, S., Schumacher, J., Watson, A. E. (1998) Equine Medicine, Surgery and Reproduction Elsevier Health Sciences
- Pascoe, R. R., Knottenbelt, D. C. (1999) Manual of Equine Dermatology Elsevier Health Sciences
- Rose, R. J., Hodgson, D. R. (2000) Manual of Equine Practice Elsevier Health Sciences
- Scott, D. W., Miller, W. H. (2003) Equine Dermatology Elsevier Health Sciences