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Coagulation Factor Deficiency (view source)

Revision as of 20:09, 29 September 2010

5 bytes added ,  20:09, 29 September 2010
→‎Factor VIII
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==Factor VIII ==
 
==Factor VIII ==
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Factor VIII is known as antihaemophilic factor (AHF); a deficiency of this factor causes 'haemophilia A'. In haemophilic conditions:
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*The primary thrombocyte plug is abnormal with more vascular channels than usual and less fibrin-collagen contact around the edges. 
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*Plugs are therefore easily dislodged which results in rebleeding.
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*Secondary plugs only form with difficulty. 
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Haemophilia is reported in horses and in around 20 breeds of dogs - it is known to be a sex-linked recessive condition associated with the X chromosome which affects only males.
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* Factor VIII is known as antihaemophilic factor (AHF).
+
The severity of the disease correlates with the Factor VIII levels. Haematomas and haemarthrosis are common lesions.
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* Deficiency of this factor causes '''haemophilia A'''.
  −
** The primary thrombocyte plug is abnormal.
  −
*** More vascular channels than usual.
  −
*** Less fibrin-collagen contact around the edges. 
  −
** Plugs are therefore easily dislodged.
  −
*** Results in rebleeding.
  −
*** Secondary plugs only form with difficulty. 
  −
* Haemophilia is reported in horses and in around 20 breeds of dogs.
  −
* Haemophilia is as a sex-linked recessive condition.
  −
** Associated with the X chromosome.
  −
** Affects males only.
  −
* The severity of the disease correlates with the Factor VIII levels.
  −
* Haematomas and haemarthrosis are common lesions.
      
==Factor IX ==
 
==Factor IX ==
Suzannah.stacey
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