Difference between revisions of "Tuberculosis - Dogs"

Revision as of 10:01, 18 October 2010

Introduction

Tuberculosis rarely affects the dog. Infection with Mycobacterium spp. is usually from a human or cattle source. Granulomatous lesions develop in various body systems. Infection with Mycobacterium tuberculosis can uncommonly result in cutaneous tuberculosis which is charcterised by ulcers, abscesses and plaques affecting the skin.

Also see general page on Tuberculosis.

Signalment

Dogs of any age or breed in contact with tuberculosis infected people or cattle.

Diagnosis

The intradermal tuberculin test can produce false negative results in the dog.

Clinical signs

Clinical signs depend on which body system is affected, associated regional lymph nodes will be enlarged in any case.

Dyspnoea
Soft productive cough
Diarrhoea
Liver failure

Radiology

Nodular soft tissue opacities will be seen in th lungs, most commonly in the caudal lung lobes.

Pathology

On post mortem examination firm multifocal nodules, with necrotic centres are found in the caudal lung lobes, liver, kidney, pleura and peritoneum. The lesions are often exudative, discharging a yellow fluid into the thorax and abdomen.

Treatment

Euthanasia is advised due to the zoonotic potential of the disease.

Links

General page on Tuberculosis

Bovine Tuberculosis

Avian Tuberculosis

References

Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition) Elsevier Science
Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial

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 ==Introduction==
-[[:Category:Mycobacterium species|''Mycobacterium'' spp.]] have a '''wide host affinity''' and pathogenic potential. They are able to survive intracellularly and produce '''granulomatous inflammations'''. Mycobacterial infections can be divided into three forms: '''tuberculous, lepromatous and opportunistic'''.
+'''Tuberculosis''' rarely affects the dog. Infection with [[:Category:Mycobacterium species|''Mycobacterium'' spp.]] is usually from a human or cattle source. Granulomatous lesions develop in various body systems. Infection with ''Mycobacterium tuberculosis'' can uncommonly result in '''cutaneous tuberculosis''' which is charcterised by ulcers, abscesses and plaques affecting the skin.
-The '''tuberculous bacteria''', ''M. tuberculosis'' and ''M. bovis'' produce nodular granulomas in their hosts.
-The ''M. avium-intercellulare'' complex (MAC) includes many saprophytic organisms that are '''opportunistic''' and produce granulomas in their hosts.
-Dogs and cats are susceptible to ''M. tuberculosis'' and ''M. bovis'' but are more resistant to infections by MAC. There appears to be a higher degree of ''M. bovis'' infection in cats.
-The incidence of true tuberculosis has decreased and rarely affects dogs and cats, but cases are seen in parts of the world where there is a high degree of exposure and where the disease is endemic.
-Dogs and cats can become disseminators when the organism localises in the intestinal or respiratory tracts.
-The '''lepromatous organism''' includes ''[[Mycobacterium lepraemurium]]'' which causes Feline Leprosy and which occurs through bites or from contact with infected rats.
-See also the general page on [[Tuberculosis|tuberculosis]].
-==Clinical signs==
-The predominant signs in small animals are '''respiratory and digestive''', but there can be some skin lesions.
-Infections are often '''asymptomatic and insidious'''.
-In '''dogs''', common signs include: fever, weight loss, anorexia and harsh non-productive coughing.
-'''Dogs and cats''' may develop hypersalivation, retching, dysphagia and tonsillar enlargement due to oropharyngeal lesions.
-'''Cats''' may have weight loss, anaemia, vomiting and diarrhoea.
+Also see general page on [[Tuberculosis]].
-'''Cutaneous lesions''' may include single or multiple ulcers, abscesses, plaques and nodules, commonly on the head, neck and limbs.
+==Signalment==
+Dogs of any age or breed in contact with tuberculosis infected people or cattle.
 ==Diagnosis==
-Intradermal skin testing in dogs and cats is '''inconsistent and unreliable'''.
+The intradermal tuberculin test can produce false negative results in the dog.
-'''Radiographs''' may show: nodular soft tissue opacities in the lungs, most commonly in the caudal lung lobes.
-The diagnosis is may by '''cytological and cultural examination''', and histopathology of biopsy material.
+===Clinical signs===
-On '''cytology''': organisms vary in number, but numerous organisms may be visible in the smear. With Wright's stain, the organisms are rod-shaped, refractile and non-staining. An '''acid-fast stain''' is needed to highlight the organism.
+Clinical signs depend on which body system is affected, associated regional lymph nodes will be enlarged in any case.
-'''Culture or PCR''' is then necessary to differentiate between mycobacterial species.
+* Dyspnoea
+* Soft productive cough
+* Diarrhoea
+* Liver failure
-The pathogen is slow-growing and requires special media and several weeks to establish visible colonies.
+===Radiology===
+Nodular soft tissue opacities will be seen in th lungs, most commonly in the caudal lung lobes.
-'''Post-mortem examination''' will reveal: firm multifocal nodules, with necrotic centres in the caudal lung lobes, liver, kidney, pleura and peritoneum. The lesions are often exudative, discharging a yellow fluid into the thorax and abdomen.
+===Pathology===
+On post mortem examination firm multifocal nodules, with necrotic centres are found in the caudal lung lobes, liver, kidney, pleura and peritoneum. The lesions are often exudative, discharging a yellow fluid into the thorax and abdomen.
 ==Treatment==
-Dogs and cats with true tuberculosis infections can be a source of infection for humans with grave consequences for public health, and in most cases '''euthanasia''' is performed.
+Euthanasia is advised due to the zoonotic potential of the disease.
-Because infections with the MAC organisms are opportunistic, usually with an environmental source, '''treatment''' may be attempted.
-'''Two or three antibacterials''' should be used intercurrently for '''6-9 months'''. Drugs such as rifampicin, clarithrocymic, clofazimine, doxycyline and enrofloxacin have been used. Treatment should be continued until all clinical signs of the disease have resolved.
-The response is '''variable''' and treatment is usually more successful in cats.
-==References==
-Hoskins, J. (2001) '''Veterinary pediatrics''' ''Elsevier Health Sciences''
-Muller, G. (2001) '''Small animal dermatology''' ''Elsevier Health Sciences''
-Ettinger, S. (2001) '''Pocket companion to textbook of veterinary internal medicine''' ''Elsevier Health Sciences''
 ==Links==
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 '''[[Mycobacterium avium|Avian Tuberculosis]]</big>
-{{Learning
+==References==
-|literature search = [http://www.cabdirect.org/search.html?q=%28title%3A%28mycobacterium+%29+OR+title%3A%28tuberculosis%29%29+AND+od%3A%28dogs%29 Canine Tuberculosis publications]
+* Blood, D.C. and Studdert, V. P. (1999) '''Saunders Comprehensive Veterinary Dictionary (2nd Edition)''' ''Elsevier Science''
-}}
+* Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
+[[Category:Dog]]
-{{review}}
-{{OpenPages}}
-[[Category:To Do - Helen]]
-[[Category:To Do - Review]]
-[[Category:Respiratory Diseases - Dog]]
 [[Category:Expert_Review]]
 [[Category:Respiratory_Bacterial_Infections]]