Difference between revisions of "Non-Infectious Arthritis"

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(Created page with " *No causative agent has been found *Seem to be immune-mediated diseases ===Erosive=== ====Rheumatoid arthritis==== *Occurs in the dog, mainly smaller breeds *Uncommon *Progre...")
 
 
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*No causative agent has been found
 
*No causative agent has been found
 
*Seem to be immune-mediated diseases
 
*Seem to be immune-mediated diseases
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===Erosive===
 
===Erosive===
  
====Rheumatoid arthritis====
+
====[[Rheumatoid Arthritis]]====
*Occurs in the dog, mainly smaller breeds
 
*Uncommon
 
*Progressive erosive polyarthritis
 
*Mostly involves elbows, stifles, carpal and tarsal joints
 
*Grossly:
 
**Marked villus hypertrophy of synovial membrane
 
**Cartilage erosion
 
**[[Musculoskeletal Terminology - Pathology|Pannus and periarticular osteophyte]] formation
 
**In severe cases ankylosis
 
*Histologically:
 
**Hyperplasia of lining cells
 
**Proliferative synovitis
 
**Synovial membrane has fibrin deposits
 
**Lymphoid and plasma cell infiltration
 
**Surrounding haemorrhagic areas
 
**Macrophages containing [[Pigmentation - Pathology#Haemosiderin|haemosiderin]]
 
**Connective tissue may contain foci of necrosis
 
**Areas of erosion of peripheral articular cartilage and underlying subchondral bone
 
*Pathogenesis:
 
**May involve deposition of immune complexes within joints
 
**Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation
 
  
  
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**Anaemia
 
**Anaemia
 
**Thrombocytopaenia
 
**Thrombocytopaenia
**[[Muscles Inflammatory - Pathology#Myositis|Polymyositis]]
+
**[[:Category:Muscles - Inflammatory Pathology|Polymyositis]]
**[[Kidney Glomerular Disease - Pathology#Glomerulonephritis|Glomerulonephritis]]
+
**[[Glomerulonephritis|Glomerulonephritis]]
  
  
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====Gout====
 
====Gout====
  
*Occurs in humans, reptiles and birds (have no uricase enzyme)
+
*Occurs in humans, [[Snake Gout|reptiles]] and birds (have no uricase enzyme)
 
*The urate triggers inflammation
 
*The urate triggers inflammation
  
 
[[Category:Arthritis]]
 
[[Category:Arthritis]]

Latest revision as of 10:01, 13 April 2011

  • No causative agent has been found
  • Seem to be immune-mediated diseases


Erosive

Rheumatoid Arthritis

Non-erosive

Systemic lupus erythematosus (SLE)


In chronic diseases


Gout

  • Occurs in humans, reptiles and birds (have no uricase enzyme)
  • The urate triggers inflammation