Difference between revisions of "Complement Flashcards"
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===Complement Fixation Pathways=== | ===Complement Fixation Pathways=== | ||
<FlashCard questions="10"> | <FlashCard questions="10"> | ||
| Line 13: | Line 6: | ||
*Alternative | *Alternative | ||
*Mannose-binding Lectin | *Mannose-binding Lectin | ||
| − | |l1=Complement | + | |l1=Complement#Compelment Fixation Pathways |
|q2=Which immunoglobulins can activate the classical pathway? | |q2=Which immunoglobulins can activate the classical pathway? | ||
|a2= | |a2= | ||
*IgM | *IgM | ||
*IgG | *IgG | ||
| − | |l2=Complement | + | |l2=Complement#Compelment Fixation Pathways |
|q3=What are the components of the C1 complex | |q3=What are the components of the C1 complex | ||
|a3= | |a3= | ||
| Line 24: | Line 17: | ||
*C1r | *C1r | ||
*C1s | *C1s | ||
| − | |l3=Complement | + | |l3=Complement#Compelment Fixation Pathways |
|q4=Which two complexes bind to make the enzyme C3 convertase? | |q4=Which two complexes bind to make the enzyme C3 convertase? | ||
|a4= | |a4= | ||
| − | * | + | *C2a |
*C4b | *C4b | ||
| − | |l4=Complement | + | |l4=Complement#Compelment Fixation Pathways |
|q5=What initiates the membrane attack complex (MAC)? | |q5=What initiates the membrane attack complex (MAC)? | ||
|a5=C3b | |a5=C3b | ||
| − | |l5=Complement | + | |l5=Complement#Compelment Fixation Pathways |
| − | |q6=What functions do the | + | |q6=What functions do the C fragments C3a, C4a, C5a and C2b have? |
|a6= | |a6= | ||
*Chemotactic for neutrophils | *Chemotactic for neutrophils | ||
| Line 39: | Line 32: | ||
*Increases vascular permeability | *Increases vascular permeability | ||
*Causes mast cell and basophil degranulation | *Causes mast cell and basophil degranulation | ||
| − | |l6=Complement | + | |l6=Complement#Compelment Fixation Pathways |
|q7=What are efficient activators of the alternative pathway? | |q7=What are efficient activators of the alternative pathway? | ||
|a7= | |a7= | ||
| Line 45: | Line 38: | ||
*Yeasts | *Yeasts | ||
*Fungi | *Fungi | ||
| − | |l7=Complement | + | |l7=Complement#Alternative Pathway |
|q8=What are the main functions of the alternative pathway? | |q8=What are the main functions of the alternative pathway? | ||
|a8= | |a8= | ||
*To coat bacteria with iC3b | *To coat bacteria with iC3b | ||
*To induce an acute inflammatory response | *To induce an acute inflammatory response | ||
| − | |l8=Complement | + | |l8=Complement#Alternative Pathway |
|q9=What are lectins? | |q9=What are lectins? | ||
|a9=Proteins which bind carbohydrates | |a9=Proteins which bind carbohydrates | ||
| − | |l9=Complement | + | |l9=Complement#MB-Lectin Pathway |
|q10=What does MASP stand for? | |q10=What does MASP stand for? | ||
|a10=Mannose-binding lectin associated proteases | |a10=Mannose-binding lectin associated proteases | ||
| − | |l10=Complement | + | |l10=Complement#MB-Lectin Pathway |
</FlashCard> | </FlashCard> | ||
| + | |||
===Complement Inhibitors=== | ===Complement Inhibitors=== | ||
<FlashCard questions="4"> | <FlashCard questions="4"> | ||
| Line 64: | Line 58: | ||
*Delay acclerating factor (DAF) | *Delay acclerating factor (DAF) | ||
**Increases the degredation of C1 esterase | **Increases the degredation of C1 esterase | ||
| − | |l1=Complement | + | |l1=Complement#Complement Inhibitors |
|q2=What do factors I and H do? | |q2=What do factors I and H do? | ||
|a2= | |a2= | ||
| Line 70: | Line 64: | ||
*Controls positive feedback by inhibiting C3b¯Bb | *Controls positive feedback by inhibiting C3b¯Bb | ||
*Prevents the complement cascade from running to exhaustion every time it is activated | *Prevents the complement cascade from running to exhaustion every time it is activated | ||
| − | |l2=Complement | + | |l2=Complement#Complement Inhibitors |
|q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? | |q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? | ||
|a3=Complement receptor 1 (CR1) | |a3=Complement receptor 1 (CR1) | ||
| − | |l3=Complement | + | |l3=Complement#Complement Inhibitors |
|q4=What does CD59 do? | |q4=What does CD59 do? | ||
|a4= | |a4= | ||
*Prevents cell lysis and pore formation | *Prevents cell lysis and pore formation | ||
*It is a protective mechanism for cells | *It is a protective mechanism for cells | ||
| − | |l4=Complement | + | |l4=Complement#Complement Inhibitors |
</FlashCard> | </FlashCard> | ||
===Functions of the Complement Cascade=== | ===Functions of the Complement Cascade=== | ||
| Line 88: | Line 82: | ||
*iC3b acts as a target for phagocytosis | *iC3b acts as a target for phagocytosis | ||
*Phagocytes bind with the complement fragments destroying the bacteria | *Phagocytes bind with the complement fragments destroying the bacteria | ||
| − | |l1=Complement | + | |l1=Complement#Functions |
|q2=What role do complement fragments have to promote inflammation? | |q2=What role do complement fragments have to promote inflammation? | ||
|a2= | |a2= | ||
*Smaller complement fragments attract granulocytes to the site of inflammation | *Smaller complement fragments attract granulocytes to the site of inflammation | ||
*Smaller complement fragments stimulate the degranulation of granulocytes | *Smaller complement fragments stimulate the degranulation of granulocytes | ||
| − | |l2=Complement | + | |l2=Complement#Functions |
|q3=By which process can C5-C9 directly kill pathogens? | |q3=By which process can C5-C9 directly kill pathogens? | ||
|a3=Cell lysis | |a3=Cell lysis | ||
| − | |l3=Complement | + | |l3=Complement#Functions |
</FlashCard> | </FlashCard> | ||
| + | |||
| + | <br><br> | ||
| + | {{Jim Bee 2007}} | ||
| + | [[Category:Immunology Flashcards]] | ||
Latest revision as of 08:20, 24 May 2012
Complement Fixation Pathways
| Question | Answer | Article | |
| What are the names of the different pathways of the complement cascade? |
|
Link to Article | |
| Which immunoglobulins can activate the classical pathway? |
|
Link to Article | |
| What are the components of the C1 complex |
|
Link to Article | |
| Which two complexes bind to make the enzyme C3 convertase? |
|
Link to Article | |
| What initiates the membrane attack complex (MAC)? | C3b
|
Link to Article | |
| What functions do the C fragments C3a, C4a, C5a and C2b have? |
|
Link to Article | |
| What are efficient activators of the alternative pathway? |
|
Link to Article | |
| What are the main functions of the alternative pathway? |
|
Link to Article | |
| What are lectins? | Proteins which bind carbohydrates
|
Link to Article | |
| What does MASP stand for? | Mannose-binding lectin associated proteases
|
Link to Article | |
Complement Inhibitors
| Question | Answer | Article | |
| Which complement inhibitor exorts control over the classical pathway and how does it function? |
|
Link to Article | |
| What do factors I and H do? |
|
Link to Article | |
| Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? | Complement receptor 1 (CR1)
|
Link to Article | |
| What does CD59 do? |
|
Link to Article | |
Functions of the Complement Cascade
| Question | Answer | Article | |
| What are the stages of opsonisation? |
|
Link to Article | |
| What role do complement fragments have to promote inflammation? |
|
Link to Article | |
| By which process can C5-C9 directly kill pathogens? | Cell lysis
|
Link to Article | |
|
Originally funded by the RVC Jim Bee Award 2007 |