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− | ===associated with derangement of carbohydrate metabolism===
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− | ====[[DM|Diabetes mellitus]]====
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− | *where there is insufficient insulin or a decrease in number of insulin receptors in cells
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− | *seen mostly in dogs
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− | *produces a markedly fatty [[Liver - Anatomy & Physiology|liver]] due to release of fat from the fat stores for use as an energy source
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− | ====Ketosis====
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− | *due to an excessive drain on carbohydrate stores because pregnant and lactating animals have a continuous demand for glucose
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− | *ketosis results when fat metabolism which occurs in response to the increased energy demand is excessive
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− | *ketone bodies accumulate in the blood and there is marked fatty change in the [[Liver - Anatomy & Physiology|liver]]
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− | *can occur in starvation but commonly seen in two conditions in livestock:
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− | =====ketosis of cattle (acetonemia)=====
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− | *occurs in high yielding dairy cows a few weeks postpartum
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− | *due to excessive loss of glucose in the milk
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− | *milk yield drops
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− | *smell of ketones on the breath
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− | *ketones excreted in the milk
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− | *self-limiting condition
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− | =====pregnancy toxaemia in sheep=====
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− | *occurs in ewes in late pregnancy carrying twin lambs ''''twin lamb disease''''
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− | *drain of carbohydrate stores is due to rapidly growing foetuses
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− | *serious condition and highly fatal
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− | *clinical signs (neurological)
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− | **apparent blindness
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− | **dullness
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− | **convulsions
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− | **coma
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− | *sequelae
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− | **foetuses die
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− | **apparent recovery in ewe until toxaemia from the decomposing foetuses results in the ewe's death
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− | ===associated with anoxia and toxaemia===
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− | ====anoxia====
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− | *passive congestion
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− | *anaemias
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− | ====toxaemia====
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− | *toxins absorbed from the gut interfere with many stages of triglyceride metabolism
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| [[Category:Liver_-_Pathology]] | | [[Category:Liver_-_Pathology]] |