Difference between revisions of "Category:Pancreas - Degenerative Pathology"

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==[[Exocrine Pancreatic Atrophy]]==
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== [[Pancreatic Atrophy, Juvenile]]==
 
  
 
 
==[[Pancreatic Autolysis]]==
 
 
 
 
==Acute pancreatic necrosis==
 
[[Image:Pancreatic necrosis.jpg|right|thumb|100px|<small><center>Pancreatic necrosis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
 
 
*(Often interchangable with [[Pancreatitis, Acute Haemorrhagic|acute pancreatitis]] or [[Pancreas Degenerative - Pathology#Exocrine pancreatic atrophy|atrophy]])
 
 
===Clinical signs===
 
*Occurs mainly in the dog, especially obese bitches, less often in cats
 
*Severe abdominal pain
 
*Cardiovascular collapse
 
*Disease may be unnoticed until signs of [[EPI|EPI]] and/or [[DM|DM]] appear terminally
 
*Death often soon follows
 
 
===Pathology===
 
*Pathological changes occur in interstitial tissue and peripancreatic adipose tissue
 
*Necrosis caused by destructive action of pancreatic enzymes (mainly phospholipase A and elastase) activated within ducts, or released into pancreatic parenchyma by rupture of ducts and then activated
 
*Followed by the release of inflammatory mediators which attracts inflammatory cells
 
*The [[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] may become involved thus causing the signs if [[DM|insulin insufficiency]]
 
*Adhesions are absent or minimal
 
 
 
 
*'''Gross appearance'''
 
** Oedematous
 
**Blood stained fluid containing [[Peritoneal Cavity Degenerative - Pathology#Abdominal fat necrosis|droplets of fat]] in the abdominal cavity
 
**Haemorrhages in the omentum may be present
 
**Areas of fat necrosis
 
**Unusually greasy texture
 
 
*'''Microscopic appearance'''
 
**Necrosis of adipose and parenchymal tissue
 
**Inflammatory infiltrate forming a border between viable and necrotic tissue
 
**Necrosis is initially perilobular  at the periphery of affected pancreatic lobules
 
**Foci of acinar tissue shrunken and acidophilic, undergoing coagulative necrosis
 
**Occlusion of capillaries, sometimes veins and small arteries, by fibrin thrombi
 
 
===Predisposing factors===
 
* are unclear
 
**Prolonged corticosteroid therapy
 
**Surgical manipulation or trauma which initiates the leakage of enzymes
 
**Obese bitches
 
**Dogs fed high fat and low protein diet
 
 
 
 
<big>'''For degenerative disease of endocrine pancreas''' see [[Endocrine Pancreas - Pathology#Degenerative pathology|Pancreas - endocrine]]
 
 
[[Healing and Repair - Pathology#The Pancreas|'''Healing of pancreas - general pathology''']]</big>
 
  
 
[[Category:Pancreas_-_Pathology]]
 
[[Category:Pancreas_-_Pathology]]

Latest revision as of 18:41, 15 February 2011

Pages in category "Pancreas - Degenerative Pathology"

The following 5 pages are in this category, out of 5 total.