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| − | ===Deficiencies of Adaptive Immunity=== | + | {{frontpage |
| | + | |pagetitle =Primary Adaptive Immunity Deficiencies |
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| | + | |contenttitle = Content |
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| − | ====Equine Severe Combined Immune Deficiency (Equine SCID)==== | + | <categorytree mode=pages>Primary Adaptive Immunity Deficiencies</categorytree> |
| − | *Autosomal recessive
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| − | *Occurs in 2-3% of Arabian foals
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| − | *Defect in DNA-dependent protein kinase gene
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| − | **Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of [[Lymphocytes|lymphocytes]] (e.g. Ig and TCR)
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| − | *No functional [[Lymphocytes#B cells|B cells]] or [[Lymphocytes#T cells|T cells]]
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| − | *Foals develop infections (usually around 8 weeks of age as maternal [[Immunoglobulins|antibody]] in [[Materno-Fetal Immunity - Introduction#Passive transfer via colostrum|colostrum]] wanes around this time)
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| − | *Foals usually die from bronchopneumonia
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| − | ====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)==== | + | |logo = Immature MDDC.png |
| − | *Affects Basset Hounds and Corgis
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| − | *X-linked recessive defect in the gene coding for the IL-2 receptor
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| − | **IL-2 receptor is a receptor for the cytokine IL-2 which causes [[Lymphocytes#T cells|T cells]] to proliferate
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| − | *Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
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| − | *Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
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| − | ====Selective [[IgA]] deficiency of German Shepherd Dogs====
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| − | *Poorly understood
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| − | *Linked to other disease syndromes such as deep pyoderma, inflammatory bowel disease, anal furunculosis and disseminated aspergillosis
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| − | *[[Immunoglobulin A|[[IgA]]]] deficiency so more susceptible to mucosal disease
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| − | ====Immunodeficiency of Weimaraners, Irish Wolfhounds and Miniature Dachshunds====
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| − | *Unknown aetiology
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| − | *Inherited defects
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| − | *Low levels of circulating [[Immunoglobulin M|IgM]] and [[Immunoglobulin G|IgG]]
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| − | *Impaired [[Neutrophils|neutrophil]] function
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| − | *Causes recurrent pyrexia and infections
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| − | **E.g. Rhinitis and bronchopneumonia in Irish Wolfhounds due to low [[Immunoglobulin A|[[IgA]]]]
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| − | **E.g. Pneumocytosis in Miniature Dachshunds due to low [[Immunoglobulin G|IgG]]
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| | [[Category:Primary Immunodeficiency]] | | [[Category:Primary Immunodeficiency]] |
