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==Pharmacokinetic Considerations==
 
==Pharmacokinetic Considerations==
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They are very lipophilic neutral small molecules, which are orally active and have a very wide volume of distribution. It is thus capable of penetrating cell membranes and will enter the CSF. It is eliminated in the liver via hepatic metabolism with only 10% being excreted in the urine unchanges. The half-life varies between each species and also with age of the animal.
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They are very lipophilic neutral small molecules, which are orally active and have a very wide volume of distribution. It is thus capable of penetrating cell membranes and will enter the CSF. It is eliminated in the liver via hepatic metabolism with only 10% being excreted in the urine unchanged. The half-life varies between each species and also with age of the animal.
 
      
==Side Effects and Contraindications==
 
==Side Effects and Contraindications==
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