Difference between revisions of "Joint Response to Injury"

Revision as of 19:43, 18 August 2008

Articular cartilage has limited ability to regenerate
- Superficial defects are long standing
  - Chondrocyte hyperplasia is ineffective at filling the defect
  - Non-painful
- Defects reaching subchondral bone
  - Filled with vascular fibroous tissue undergoing metaplasia into cartilage
  - Painful
- Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
- Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
Synovial membranes respond by:
- Villous hypertrophy
  - +/- synovitis
- Hyperplasia

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+===Causes of injury ===
+*Trauma
+*Instability
+*Lubrication failure
+*Infectious organisms
+*Immune-mediated disease
+===Reaction to injury===
+*[[Joints - normal#Articular cartilage|Articular cartilage]] has limited ability to regenerate
+**Superficial defects are long standing
+***Chondrocyte hyperplasia is ineffective at filling the defect
+***Non-painful
+**Defects reaching subchondral bone
+***Filled with vascular fibroous tissue undergoing [[General Pathology - Disorders of Cell Growth#Metaplasia|metaplasia]] into cartilage
+***Painful
+**Fibrillation - loss of proteoglycans -> condensation of collagen fibres -> fraying of surface
+**Eburnation - loss of articular cartilage -> exposure of subchondral bone -> becomes dense and polished
+*Synovial membranes respond by:
+**Villous hypertrophy
+***+/- [[Joints - inflammatory|synovitis]]
+**Hyperplasia