Difference between revisions of "Muscle Development - Anatomy & Physiology"
Jump to navigation
Jump to search
| Line 4: | Line 4: | ||
Muscle cells can come from two lineages in the somite. Limb and body muscle develop from hypaxial muscle in the lateral regions of the somite. Back muscle develops from epaxial muscle in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium. | Muscle cells can come from two lineages in the somite. Limb and body muscle develop from hypaxial muscle in the lateral regions of the somite. Back muscle develops from epaxial muscle in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium. | ||
| + | |||
| + | |||
| + | ==Muscle Development== | ||
| + | |||
| + | #'''Prescursor''' cells migrate from the dermomyotome. | ||
| + | #*They are mesenchymal | ||
| + | #*Divide rapidly en route and are undifferentiated. | ||
| + | #Cells differentiate to form '''myoblasts'''. | ||
| + | #*Cells still mesenchymal but can no longer migrate as differentiated. | ||
| + | #*Muscle gene expression. | ||
| + | #The '''myotube''' is formed; cells become multi - nucleated to form a syncytium. | ||
| + | #*Muscle enzymes are produced. | ||
| + | #The '''myofibre''' is produced. | ||
| + | #*Contractile proteins are present. | ||
Revision as of 08:29, 31 August 2008
Introduction
Muscle cells can come from two lineages in the somite. Limb and body muscle develop from hypaxial muscle in the lateral regions of the somite. Back muscle develops from epaxial muscle in the dorsal regions of the somite. Muscle fibres have hundreds of nuclei and function as a syncytium.
Muscle Development
- Prescursor cells migrate from the dermomyotome.
- They are mesenchymal
- Divide rapidly en route and are undifferentiated.
- Cells differentiate to form myoblasts.
- Cells still mesenchymal but can no longer migrate as differentiated.
- Muscle gene expression.
- The myotube is formed; cells become multi - nucleated to form a syncytium.
- Muscle enzymes are produced.
- The myofibre is produced.
- Contractile proteins are present.