Difference between revisions of "Complement Flashcards"
Jump to navigation
Jump to search
(New page: {{toplink |backcolour = FFE4E1 |linkpage =Complement - WikiBlood |linktext =COMPLEMENT |sublink1 =Flash Cards - WikiBlood |subtext1 =WIKIBLOOD FLASHCARDS |pagetype =Blood }} ==<font color...) |
|||
| Line 1: | Line 1: | ||
{{toplink | {{toplink | ||
| − | |||
|linkpage =Complement - WikiBlood | |linkpage =Complement - WikiBlood | ||
|linktext =COMPLEMENT | |linktext =COMPLEMENT | ||
| Line 7: | Line 6: | ||
|pagetype =Blood | |pagetype =Blood | ||
}} | }} | ||
| − | + | ===Complement Fixation Pathways=== | |
| − | == | + | <FlashCard questions="10"> |
| − | + | |q1=What are the names of the different pathways of the complement cascade? | |
| − | + | |a1= | |
| − | + | *Classical | |
| − | + | *Alternative | |
| − | + | *Mannose-binding Lectin | |
| − | + | |l1=Complement - WikiBlood#Compelment Fixation Pathways | |
| − | | | + | |q2=Which immunoglobulins can activate the classical pathway? |
| − | * | + | |a2= |
| − | * | + | *IgM |
| − | * | + | *IgG |
| − | | | + | |l2=Complement - WikiBlood#Compelment Fixation Pathways |
| − | + | |q3=What are the components of the C1 complex | |
| − | + | |a3= | |
| − | | | + | *C1q |
| − | * | + | *C1r |
| − | * | + | *C1s |
| − | | | + | |l3=Complement - WikiBlood#Compelment Fixation Pathways |
| − | + | |q4=Which two complexes bind to make the enzyme C3 convertase? | |
| − | + | |a4= | |
| − | | | + | *C2b |
| − | * | + | *C4b |
| − | * | + | |l4=Complement - WikiBlood#Compelment Fixation Pathways |
| − | * | + | |q5=What initiates the membrane attack complex (MAC)? |
| − | | | + | |a5=C3b |
| − | + | |l5=Complement - WikiBlood#Compelment Fixation Pathways | |
| − | + | |q6=What functions do the Ca fragments have? | |
| − | | | + | |a6= |
| − | * | + | *Chemotactic for neutrophils |
| − | * | + | *Induces acute inflammation |
| − | | | + | *Increases vascular permeability |
| − | + | *Causes mast cell and basophil degranulation | |
| − | + | |l6=Complement - WikiBlood#Compelment Fixation Pathways | |
| − | | | + | |q7=What are efficient activators of the alternative pathway? |
| − | + | |a7= | |
| − | | | + | *Gram-negative bacteria |
| − | + | *Yeasts | |
| − | + | *Fungi | |
| − | | | + | |l7=Complement - WikiBlood#Alternative Pathway |
| − | * | + | |q8=What are the main functions of the alternative pathway? |
| − | * | + | |a8= |
| − | * | + | *To coat bacteria with iC3b |
| − | * | + | *To induce an acute inflammatory response |
| − | | | + | |l8=Complement - WikiBlood#Alternative Pathway |
| − | + | |q9=What are lectins? | |
| − | + | |a9=Proteins which bind carbohydrates | |
| − | | | + | |l9=Complement - WikiBlood#MB-Lectin Pathway |
| − | * | + | |q10=What does MASP stand for? |
| − | * | + | |a10=Mannose-binding lectin associated proteases |
| − | * | + | |l10=Complement - WikiBlood#MB-Lectin Pathway |
| − | | | + | </FlashCard> |
| − | + | ===Complement Inhibitors=== | |
| − | + | <FlashCard questions="4"> | |
| − | | | + | |q1=Which complement inhibitor exorts control over the classical pathway and how does it function? |
| − | * | + | |a1= |
| − | * | + | *Delay acclerating factor (DAF) |
| − | | | + | **Increases the degredation of C1 esterase |
| − | + | |l1=Complement - WikiBlood#Complement Inhibitors | |
| − | + | |q2=What do factors I and H do? | |
| − | | | + | |a2= |
| − | + | *Breaks down C3b | |
| − | | | + | *Controls positive feedback by inhibiting C3b¯Bb |
| − | + | *Prevents the complement cascade from running to exhaustion every time it is activated | |
| − | + | |l2=Complement - WikiBlood#Complement Inhibitors | |
| − | | | + | |q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? |
| − | + | |a3=Complement receptor 1 (CR1) | |
| − | | | + | |l3=Complement - WikiBlood#Complement Inhibitors |
| − | + | |q4=What does CD59 do? | |
| − | + | |a4= | |
| − | + | *Prevents cell lysis and pore formation | |
| − | == | + | *It is a protective mechanism for cells |
| − | + | |l4=Complement - WikiBlood#Complement Inhibitors | |
| − | + | </FlashCard> | |
| − | + | ===Functions of the Complement Cascade=== | |
| − | + | <FlashCard questions="3"> | |
| − | + | |q1=What are the stages of opsonisation? | |
| − | + | |a1= | |
| − | | | + | *The complement system deposits a shell of protein on the bacterial cell surface, e.g. complement fragments |
| − | * | + | *Complement fragments released are chemotactic for phagocytes |
| − | ** | + | *iC3b acts as a target for phagocytosis |
| − | | | + | *Phagocytes bind with the complement fragments destroying the bacteria |
| − | + | |l1=Complement - WikiBlood#Functions | |
| − | + | |q2=What role do complement fragments have to promote inflammation? | |
| − | | | + | |a2= |
| − | * | + | *Smaller complement fragments attract granulocytes to the site of inflammation |
| − | * | + | *Smaller complement fragments stimulate the degranulation of granulocytes |
| − | * | + | |l2=Complement - WikiBlood#Functions |
| − | | | + | |q3=By which process can C5-C9 directly kill pathogens? |
| − | + | |a3=Cell lysis | |
| − | + | |l3=Complement - WikiBlood#Functions | |
| − | | | + | </FlashCard> |
| − | |||
| − | | | ||
| − | |||
| − | |||
| − | | | ||
| − | * | ||
| − | * | ||
| − | | | ||
| − | |||
| − | |||
| − | |||
| − | |||
| − | == | ||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | | | ||
| − | * | ||
| − | * | ||
| − | * | ||
| − | * | ||
| − | | | ||
| − | |||
| − | |||
| − | | | ||
| − | * | ||
| − | * | ||
| − | | | ||
| − | |||
| − | |||
| − | | | ||
| − | |||
| − | | | ||
| − | |||
| − | |||
| − | |||
Revision as of 11:14, 20 February 2010
|
Complement Fixation Pathways
| Question | Answer | Article | |
| What are the names of the different pathways of the complement cascade? |
|
Link to Article | |
| Which immunoglobulins can activate the classical pathway? |
|
Link to Article | |
| What are the components of the C1 complex |
|
Link to Article | |
| Which two complexes bind to make the enzyme C3 convertase? |
|
Link to Article | |
| What initiates the membrane attack complex (MAC)? | C3b
|
Link to Article | |
| What functions do the Ca fragments have? |
|
Link to Article | |
| What are efficient activators of the alternative pathway? |
|
Link to Article | |
| What are the main functions of the alternative pathway? |
|
Link to Article | |
| What are lectins? | Proteins which bind carbohydrates
|
Link to Article | |
| What does MASP stand for? | Mannose-binding lectin associated proteases
|
Link to Article | |
Complement Inhibitors
| Question | Answer | Article | |
| Which complement inhibitor exorts control over the classical pathway and how does it function? |
|
Link to Article | |
| What do factors I and H do? |
|
Link to Article | |
| Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis? | Complement receptor 1 (CR1)
|
Link to Article | |
| What does CD59 do? |
|
Link to Article | |
Functions of the Complement Cascade
| Question | Answer | Article | |
| What are the stages of opsonisation? |
|
Link to Article | |
| What role do complement fragments have to promote inflammation? |
|
Link to Article | |
| By which process can C5-C9 directly kill pathogens? | Cell lysis
|
Link to Article | |