Difference between revisions of "Immunodeficiencies - WikiBlood"
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==Primary Immunodeficiency== | ==Primary Immunodeficiency== | ||
| − | === | + | ===Deficiencies of Innate Immunity=== |
| − | + | *Canine Cyclic Haematopoiesis | |
| − | === | + | *Canine Leukocyte Adhesion Deficiency (CLAD) |
| + | |||
| + | *Bovine Leukocyte Adhesion Deficiency (BLAD) | ||
| + | |||
| + | ===Deficiencies of Adaptive Immunity=== | ||
| + | |||
| + | *Equine & Canine Severe Combined Immune Deficiency (SCID) | ||
| + | |||
| + | *Selective IgA deficiency of German Shepherd Dogs | ||
| + | |||
| + | *Immunodeficiency of Weimaraners | ||
| + | |||
| + | *Rhinitis/Bronchopneumonia in Irish Wolfhounds | ||
| + | |||
| + | *Pneumocystis infection in Miniature Dachshunds | ||
===Severe Combined Deficiency=== | ===Severe Combined Deficiency=== | ||
| + | |||
| + | *Severe Combined Immune Deficiency(SCID) | ||
| + | **No functional B or T cells | ||
| + | |||
| + | *Arthymic nude mice (no thymus) | ||
| + | **No functional T cells | ||
| + | |||
| + | *Knock-out muce | ||
| + | **E.g. Gene coding for CD4, CD8, IL-10 removed | ||
==Secondary Immunodeficiency== | ==Secondary Immunodeficiency== | ||
| + | |||
| + | ===Viral Causes=== | ||
| + | |||
| + | *Feline Leukaemia Virus (FeLV) | ||
| + | |||
| + | *Feline Immunodeficiency Virus (FIV) | ||
| + | |||
| + | *Bovine Immunodeficiency Virus (BIV) | ||
| + | |||
| + | ===Toxic Causes=== | ||
| + | |||
| + | *Poisons | ||
| + | |||
| + | ===Iatrogenic Causes=== | ||
| + | |||
| + | *Drugs | ||
| + | **Corticosteroids | ||
| + | **Ciclosporin | ||
| + | **Cytoxic cancer therapy | ||
| + | |||
| + | ===Other Causes=== | ||
| + | |||
| + | *Malnutrition | ||
| + | |||
| + | *Chronic disease | ||
| + | |||
| + | *Stress | ||
| + | |||
| + | *Senescence | ||
==Links== | ==Links== | ||
Revision as of 14:47, 6 September 2008
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Introduction
Like any system in the body the immune system can go wrong. Autoimmunity is when the immune system begins to attack itself. Immunodeficiency is when the immune system fails to protect itself from disease.
If the immunodeficient defect is present at birth and is therefore a result of a genetic or developmental abnormality, it is called primary immunodeficiency.
Secondary immunodeficiency, soemtimes called aquired immunodeficiency, is the loss of immune function during life, caused by exposure to harmful agents.
Primary Immunodeficiency
Deficiencies of Innate Immunity
- Canine Cyclic Haematopoiesis
- Canine Leukocyte Adhesion Deficiency (CLAD)
- Bovine Leukocyte Adhesion Deficiency (BLAD)
Deficiencies of Adaptive Immunity
- Equine & Canine Severe Combined Immune Deficiency (SCID)
- Selective IgA deficiency of German Shepherd Dogs
- Immunodeficiency of Weimaraners
- Rhinitis/Bronchopneumonia in Irish Wolfhounds
- Pneumocystis infection in Miniature Dachshunds
Severe Combined Deficiency
- Severe Combined Immune Deficiency(SCID)
- No functional B or T cells
- Arthymic nude mice (no thymus)
- No functional T cells
- Knock-out muce
- E.g. Gene coding for CD4, CD8, IL-10 removed
Secondary Immunodeficiency
Viral Causes
- Feline Leukaemia Virus (FeLV)
- Feline Immunodeficiency Virus (FIV)
- Bovine Immunodeficiency Virus (BIV)
Toxic Causes
- Poisons
Iatrogenic Causes
- Drugs
- Corticosteroids
- Ciclosporin
- Cytoxic cancer therapy
Other Causes
- Malnutrition
- Chronic disease
- Stress
- Senescence
Links
Immunodeficiencies Flashcards
References
- Ivan Roitt: Essential Immunology, Ninth edition
- Goldsby, Kindt, & Osbourne KUBY Immunology, Fourth edition
- B.Catchpole RVC