Difference between revisions of "Leishmania"
Jump to navigation
Jump to search
Line 82: | Line 82: | ||
***E.g. ''T. vivax'' | ***E.g. ''T. vivax'' | ||
***Decreases the chances of [[Biting Flies|fly]] infection | ***Decreases the chances of [[Biting Flies|fly]] infection | ||
− | **Trypanosomes avoid host immune defences by altering glycoprotein coat (surface antigen) before host [[ | + | **Trypanosomes avoid host immune defences by altering glycoprotein coat (surface antigen) before host [[Immunoglobulins - WikiBlood|antibody]] response |
***'''Antigenic variation''' can occur many times over several months causes relapsing parasitaemia | ***'''Antigenic variation''' can occur many times over several months causes relapsing parasitaemia | ||
Revision as of 16:35, 23 November 2008
This article is still under construction. |
|
Trypanosoma
- Protozoal parasites found in the blood and tissues of vertebrates
- Worldwide distribution
- Causes sleeping sickness in humans
- Particularly affect sub-Saharan Africa
- Affect cattle production
- Cause Nagana (depression)
- Divided into two groups depending on the mode of development of the insect vector
- Salivarian
- Multiply in the foregut
- Transmitted via innoculation via feeding
- Stercorarian'
- Multiply in the hindgut
- Transmitted via contamination of wounds with insect faeces
- Salivarian
Life Cycle
- Undergo morphological transformations in intermediate host before becoming infective for the next host
- Blood-sucking flies ingest trypanosomes whilst taking a blood meal from an infected animal
- Trypanosomes multiply first in the gut of the fly
- Salivarian trypanosomes are transmitted by Tsetse flies
- Trypanosomes pass foward to the salivary glands where they transform into the infective stage
- Innoculated with saliva when Tsetse fly next feeds on a host
- Stercorarian trypanosomes are transmitted by triatomid bugs, tabanids and keds
- Trypanosomes pass back to the rectum
- Next host is infected when skin wounds are contaminated with infected insect faeces
Pathogenesis
- Salivarian
- Causes wasting disease in cattle (nagana)
- Sleeping sickness in humans
- Stercorarian
- T. cruzi most important in veterinary medicine
- Occurs in South America
- Infects armadillos, possums and humans
- Causes Chagas Disease
- Transmitted by a triatomid (kissing) bug
- Chronic infections are often fatal causing heart failure
- Non-pathogenic species are transmitted by tabanids and keds
- T. theileria and T. melophagium
- T. cruzi most important in veterinary medicine
- Enlarged lymph nodes and spleen
- Causes lymphoid exhaustion
- Anaemia
- Red blood cells removed from circulation
- Degeneration and inflammation of multiple organs
- E.g. Skeletal muscle, myocardium and CNS
Epidemiology
- Vector distribution
- Tsetse flies found in riverine, savannah and forest habitats
- Up to 20% flies infected
- Flies infected for life
- Parasite virulence
- Some parasitaemic animals survive for long periods of time
- E.g. T. brucei and T. congolense
- Increases the opportunity for infection of flies
- Some trypanosomes kill their host in 1-2 weeks
- E.g. T. vivax
- Decreases the chances of fly infection
- Trypanosomes avoid host immune defences by altering glycoprotein coat (surface antigen) before host antibody response
- Antigenic variation can occur many times over several months causes relapsing parasitaemia
- Some parasitaemic animals survive for long periods of time
- Host response
- Trypanotolerant wild animals remain parasitaemic for prolpnged periods without showing clincial signs of disease
- Cause lasting reservoirs of infection
- Most domestic livestock are susceptible to trypanosomosis
- Some local breeds of sheep, goats and cattle are trypanotolerant
- E.g. Bos indicus
- Trypanotolerant wild animals remain parasitaemic for prolpnged periods without showing clincial signs of disease
Diagnosis
- Demonstrate trypanosomes in blood
- Giemsa stained smears
- Fresh blood films
- Motile trypanosomes
- Haematocrit tube
- Motile trypanosomes at the plasma/buffy coat interface
Control
- Tsetse fly control
- Spraying and trapping
- Prophylactic drug treatment
- Change drug group periodically to decrease the chances of resistance occuring
- May lead to protective immunity but livestock will still be susceptible to heterologous challenges
- Barrier fences and buffer zones
- Separate livestock and wild animals
- Trypanotolerant livestock
Other trypanosomes
- Mechanically transmitted by biting flies
- E.g. Surra affecting horses and camels in North Africa, Asia and South America
- T. equinum in South America
- T. evansi in Asia
- Venerally transmitted
- E.g. Dourine
- Transmitted by T. equiperdum
- Causes genital and abdominal oedema, emaciataion and CNS signs
- Affects horses and donkeys in Africa, Asia, Central and South America
- E.g. Dourine
- Non-pathogenic species occur in the UK
- In sheep caused by T. melophagium
- In cattle caused by T. theileri
Leishmania
Life Cycle
Pathogenesis
Leishmania involved in skin infections
Epidemiology
Diagnosis
Treatment and Control