Difference between revisions of "NSAIDs"
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==Mechanism of Action== | ==Mechanism of Action== | ||
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| + | NSAIDs are defined as "''agents which inhibit the formation of eicosanoids from arachidonic acid''". Prostaglandins, thromboxanes and leukotrienes are all eicosanoids which have an inflammatory-mediating action. | ||
==Spectrum of Activity== | ==Spectrum of Activity== | ||
Revision as of 18:03, 27 January 2009
The term "NSAIDs" stands for non-steroidal anti-inflammatory drugs. They were originially obtained from plant extracts such as willow bark, which contain agents known as salicylates. Aspirin was synthesised for the first time in 1893, and in 1972 the mode of NSAID action was discovered to be associated with cyclo-oxygenase inhibition.
Mechanism of Action
NSAIDs are defined as "agents which inhibit the formation of eicosanoids from arachidonic acid". Prostaglandins, thromboxanes and leukotrienes are all eicosanoids which have an inflammatory-mediating action.