Author, Donkey, Bureaucrats, Administrators
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==Prescribing for donkeys==
==Prescribing for donkeys==
[[Image:Donkey Mexico.JPG|thumb|right|200px|<small><center>Image courtesy of [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary]</center></small>]]
Pharmacokinetic differences have been demonstrated between horses and donkeys for a number of drugs e.g. oxytetracycline (Horspool ''et al'', 1990), trimethoprim-sulfamethoxazole (Peck ''et al'', 2002), phenylbutazone (Mealey ''et al'', 1997, Matthews ''et al'', 2001), flunixin meglumine (Coakley ''et al'', 1999), and guaifenesin (Matthews ''et al'', 1997) with, in general, Vd being lower, CL being higher and/or t½ being shorter in donkeys than in horses. These differences are of potential clinical significance for some, but not all, drugs that undergo hepatic biotransformation (Peck ''et al'', 1997). The NSAID carprofen is apparently metabolised more slowly in donkeys than in horses (Mealey 'et al'', 2004).
Pharmacokinetic differences have been demonstrated between horses and donkeys for a number of drugs e.g. oxytetracycline (Horspool ''et al'', 1990), trimethoprim-sulfamethoxazole (Peck ''et al'', 2002), phenylbutazone (Mealey ''et al'', 1997, Matthews ''et al'', 2001), flunixin meglumine (Coakley ''et al'', 1999), and guaifenesin (Matthews ''et al'', 1997) with, in general, Vd being lower, CL being higher and/or t½ being shorter in donkeys than in horses. These differences are of potential clinical significance for some, but not all, drugs that undergo hepatic biotransformation (Peck ''et al'', 1997). The NSAID carprofen is apparently metabolised more slowly in donkeys than in horses (Mealey 'et al'', 2004).