Difference between revisions of "Pseudomonas aeruginosa"
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(Created page with '*Causes opportunistic infections requiring predisposing factors *Pathogenesis: **Grows on few nutrients and can survive certain disinfectants **Toxins and enzymes such as exotoxi…') |
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**Gentamicin or tobramycin with carbenicillin or ticarcillin, as well as polymyxin B are effective | **Gentamicin or tobramycin with carbenicillin or ticarcillin, as well as polymyxin B are effective | ||
[[Category:Pseudomonas_and_Burkholderia_species]] | [[Category:Pseudomonas_and_Burkholderia_species]] | ||
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Revision as of 10:56, 25 June 2010
- Causes opportunistic infections requiring predisposing factors
- Pathogenesis:
- Grows on few nutrients and can survive certain disinfectants
- Toxins and enzymes such as exotoxin A, phospholipase C and proteases allow tissue invasion and damage
- Elastase damages elastin in lung parenchyma and blood vessel walls
- Attachment to host cells via fimbrae
- Resists phagocytosis and complement via its LPS
- Obtains iron from tissues
- Clinical infections:
- Haemorrhagic pneumonia and septicaemia in mink with 50% mortality via a secondary thrombocytopenic disease
- Bovine mastitis associated with contaminated water used for washing udders; also metritis, pneumonia, dermatitis and enteritis in cattle
- Ovine fleece rot - suppurative dermatitis after penetration of water into fleece; wool discoloured by pyocyanin pigment; also mastitis, pneumonia, otitis media
- Necrotic stomatitis in captive reptiles
- Respiratory infections and otitis in pigs
- Genital tract infections, pneumonia, ulcerative keratitis in horses
- Otitis externa, cystitis, pneumonia, ulcerative keratitis in dogs and cats
- Causes deep pyoderma
- Diagnosis:
- Specimens should include pus, respiratory aspirates, mid-stream urine and ear swabs
- Identify colonies on blood and MacConkey agar
- Oxidative not fermentative
- Only grow in aerobic conditions
- Produces diffusable pigments including pyocyanin, a green pigment, and fluorescine
- Grow on MacConkey agar; colonies have a fruity odour; lactose negative, pale colonies on MacConkey
- Treatment:
- Multiple antibiotic resistance mediated by large plasmids carrying resistance genes and also chromosomal genes and mutations
- Gentamicin or tobramycin with carbenicillin or ticarcillin, as well as polymyxin B are effective