Difference between revisions of "Hepatic Microvascular Dysplasia"

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(Created page with '*Small intrahepatic portal vessels and portal endothelial hyperplasia which allows abnormal communication between portal and systemic circulation. *Can develop as a separate enti…')
 
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*Higher MCV, serum postprandial bile acid concentrations, serum albumin and cholesterol concentrations when PSS and HMD together, compared to HMD alone.
 
*Higher MCV, serum postprandial bile acid concentrations, serum albumin and cholesterol concentrations when PSS and HMD together, compared to HMD alone.
 
[[Category:Liver_-_Developmental_Pathology]]
 
[[Category:Liver_-_Developmental_Pathology]]
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[[Category:To_Do_-_Clinical]]

Revision as of 20:41, 28 June 2010

  • Small intrahepatic portal vessels and portal endothelial hyperplasia which allows abnormal communication between portal and systemic circulation.
  • Can develop as a separate entity or in conjunction with a portosystemic shunt.
  • Can cause c/s similar to those of PSS.
  • Vomiting, diarrhoea, urinary tract changes associated with ammonium biurate urolithiasis, stunted growth, prolonged recovery from anesthesia.
  • Average age of presentation =3yrs.
  • Mainly small dogs, esp. Yorkies
  • Females>males

Histology

    • Arteriolarization of central veins
    • smooth muscle proliferation (segmental) within the walls of central veins
    • random distribution of small calibre vessels
    • endothelial hyperplasia within portal triads
    • dilation of periacinar vascular spaces.
    • May also see decreased diameter of intrahepatic veins.
  • Can’t be accurately distinguished from PSS alone.
  • Seen in older dogs than PSS
  • Higher MCV, serum postprandial bile acid concentrations, serum albumin and cholesterol concentrations when PSS and HMD together, compared to HMD alone.