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<p>Leukopoiesis is the process of formation of [[Leukocytes|leukocytes]] (white blood cells) from stem cells in haematopoietic organs. Leukocytes develop from either multipotential myeloid stem cells ([[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]]) or multipotential lymphoid stem cells ([[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-L]]). </p>

<p>Leukopoiesis is the process of formation of [[Leukocytes|leukocytes]] (white blood cells) from stem cells in haematopoietic organs. Leukocytes develop from either multipotential myeloid stem cells ([[Haematopoiesis#Colony Forming Units|CFU-GEMM]]) or multipotential lymphoid stem cells ([[Haematopoiesis#Colony Forming Units|CFU-L]]). </p>

<p>[[Leukocytes|Leukocytes]] developing from CFU-GEMM’s are granulocytes ([[Neutrophils|neutrophils]], [[Basophils| basophils]] and [[Eosinophils| eosinophils]]) or [[Monocytes|monocytes]] and [[Leukocytes|leukocytes]] developing from [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-L]]'s are lymphocytes (T & B cells, dendritic and NK cells).</p>

<p>[[Leukocytes|Leukocytes]] developing from CFU-GEMM’s are granulocytes ([[Neutrophils|neutrophils]], [[Basophils| basophils]] and [[Eosinophils| eosinophils]]) or [[Monocytes|monocytes]] and [[Leukocytes|leukocytes]] developing from [[Haematopoiesis#Colony Forming Units|CFU-L]]'s are lymphocytes (T & B cells, dendritic and NK cells).</p>

[[Image:Leukopoiesis pathway.jpg|right|thumb|400px|'''Leukopoiesis pathway''']]

[[Image:Leukopoiesis pathway.jpg|right|thumb|400px|'''Leukopoiesis pathway''']]

==Granulopoiesis==

==Granulopoiesis==

All granulocytes develop from the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] cells.

All granulocytes develop from the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] cells.

===Summary of pathways===

===Summary of pathways===

<div style="text-align: center;">

<div style="text-align: center;">

===[[Neutrophils|Neutrophils]]===

===[[Neutrophils|Neutrophils]]===

Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-G]].

Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-G]].

====Stages====

====Stages====

=====Myeloblast=====

=====Myeloblast=====

<br>

<br>

===[[Basophils|Basophils]]===

===[[Basophils|Basophils]]===

Under the stimulation of GM-CSF and Il-3 the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Ba]].

Under the stimulation of GM-CSF and Il-3 the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-Ba]].

====Stages====

====Stages====

===== Myeloblast & Promyelocyte=====

===== Myeloblast & Promyelocyte=====

===[[Eosinophils|Eosinophils]]===

===[[Eosinophils|Eosinophils]]===

Under the stimulation of GM-CSF, Il-3 and Il-5 the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GEMM]] differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-Eo]].

Under the stimulation of GM-CSF, Il-3 and Il-5 the [[Haematopoiesis#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-Eo]].

====Stages====

====Stages====

===== Myeloblast & Promyelocyte=====

===== Myeloblast & Promyelocyte=====

==Monocyte development==

==Monocyte development==

[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.

[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.

===Stages===

===Stages===

====Monoblast====

====Monoblast====

First stage after cell has differentiated into the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-M]].

First stage after cell has differentiated into the [[Haematopoiesis#Colony Forming Units|CFU-M]].

====Promonocyte====

====Promonocyte====

Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).

Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).

==Lymphopoiesis==

==Lymphopoiesis==

<p>[[Lymphocytes|Lymphocytes]] develop from the [[Overview of Haematopoiesis - WikiBlood#Colony Forming Units|CFU-L]]'s. Those destined to become [[Lymphocytes#T cells|T cells]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] and migrate to the [[Thymus - Anatomy & Physiology|thymus]], and those destined to be [[Lymphocytes#B cells|B cells]] migrate to the [[Spleen - Anatomy & Physiology|spleen]] and GALT or proliferate directly from the [[Bone Marrow - Anatomy & Physiology|bone marrow]].</p><p>Follow these links for a more detailed explanation on [[T cell differentiation - WikiBlood|T cell development]] and [[B cell differentiation - WikiBlood |B cell development]].</p>

<p>[[Lymphocytes|Lymphocytes]] develop from the [[Haematopoiesis#Colony Forming Units|CFU-L]]'s. Those destined to become [[Lymphocytes#T cells|T cells]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] and migrate to the [[Thymus - Anatomy & Physiology|thymus]], and those destined to be [[Lymphocytes#B cells|B cells]] migrate to the [[Spleen - Anatomy & Physiology|spleen]] and GALT or proliferate directly from the [[Bone Marrow - Anatomy & Physiology|bone marrow]].</p><p>Follow these links for a more detailed explanation on [[T cell differentiation - WikiBlood|T cell development]] and [[B cell differentiation - WikiBlood |B cell development]].</p>

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