Difference between revisions of "Viral skin infections - Pathology"

Revision as of 10:59, 30 June 2010

Lesion development:
- Due to viral invasion of epithelium
- Vascular injury -> ischaemic necrosis
- Stimulation of host DNA -> hyperplastic nodules
Cutaneous lesions:
- Macule -> papule -> vesicle -> umbilicated pustule -> crust -> scar

Contagious ecthyma (Courtesy of Bristol BioMed Image Archive)

Also called contagious pustular dermatitis, orf, sore mouth
Caused by a parapox virus
Affects mainly young sheep, less commonly cattle, humans, dogs
Starts in abrasions around mouth commisures and spreads to lips, oral mucosa, eyelids and feet
May also transfer to teats of the mother of an affected lamb
Lesions typical of poxvirus but very brief vesicle stage
Most obvious is the proliferative pustular stage

@@ Line 12: / Line 12: @@
 <br>
 ===[[Herpesviridae|Herpesviruses]]===
+[[Herpesvirus Skin Infections]]
-*Cutaneous lesions may develop with nondermatotropic viruses:
-**[[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|Infectious bovine rhinotracheitis]] (bovine herpes virus - 1)
-**Equine coital exanthema (equine herpes virus - 3)
-**[[Respiratory Viral Infections - Pathology#Feline viral rhinotracheitis|Feline herpes virus -1]] (rarely)
-*Dermatotropic viruses:
-[[Bovine Herpesvirus 2]]
-*May be latent and reappear at times of stress
-*Grossly:
-**[[Skin Glossary - Pathology|Vesicles, ulcers, crusts]]
-*Microscopically:
-**Intraepidermal vesicle
-**Epidermal cell degeneration
-**[[Skin Glossary - Pathology|Acantholysis]]
-**Syncytial cells may form
-**Intracellular inclusion bodies may be found at edges of ulcers
-**Rapid necrosis
 ===[[Poxviruses]]===