Difference between revisions of "Caprine Arthritis Encephalitis Virus"
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*Can be confused with or coexisting with [[Lungs Inflammatory - Pathology#Verminous pneumonia|Parasitic pneumonia]] | *Can be confused with or coexisting with [[Lungs Inflammatory - Pathology#Verminous pneumonia|Parasitic pneumonia]] | ||
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| + | **Arthritis is commonly the main expression | ||
| + | **Large limb joints are thickened | ||
| + | **'''Carpal hygroma''' is often present | ||
| + | ***Subcutaneous cystic swelling on cranial surface of the knee, contains serous fluid | ||
| + | **In advanced cases | ||
| + | ***Synovial villus hypertrophy | ||
| + | ***Necrosis | ||
| + | ***Mineralisation | ||
| + | ***Mononuclear cell infiltration | ||
| + | ***[[Musculoskeletal Terminology - Pathology|Pannus]] formation | ||
| + | ***[[Joints - Anatomy & Physiology#Articular cartilage|Articular cartilage]] destruction | ||
[[Category:Lentiviruses]][[Category:Goat]][[Category:To_Do_-_Viruses]] | [[Category:Lentiviruses]][[Category:Goat]][[Category:To_Do_-_Viruses]] | ||
Revision as of 10:22, 1 July 2010
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This article is still under construction. |
CAEV
Antigenicity
- Serologically related to Visna-Maedi with antigenic and genetic envelope differences
Hosts
- Goats
Pathogenesis
- T cells induce immune complex disease
- Causes encephalitis of kids or insidious polyarthritis of adults
- Also causes pneumonia
Epidemiology
- Transfer via milk and colostrum, particularly batch-mixing
- Present in 10% of UK herds
- Clinical disease is rare
Diagnosis
- Visna-Maedi serology (ELISA) test can be used to remove positive stock
Control
- Separate kids from virus positive mothers at birth
- Treat mother's colostrum (56 deg for 1 hour)
- Rear on artificial milk
Caprine Arthritis-Encephalitis (CAE)
- Caused by retrovirus (lentivirus) similar to Maedi Visna in sheep described above
- Two forms:
- Non-suppurative leukoencephalomyelitis in young goats and kids
- Chronic, non-suppurative arthritis-synovitis in adult goats
- Also causes interstitial pneumonia which tends to be obscured by other clinical signs
- Gross pathology:
- Mainly caudal lobes
- Lungs are firm, grey-pink with grey-white focal lesions on cut surface
- Micro pathology:
- Thickened alveolar wall
- Lymphocyte infiltration and type II pneumocyte hyperplasia
- Can be confused with or coexisting with Parasitic pneumonia
- Arthritis is commonly the main expression
- Large limb joints are thickened
- Carpal hygroma is often present
- Subcutaneous cystic swelling on cranial surface of the knee, contains serous fluid
- In advanced cases
- Synovial villus hypertrophy
- Necrosis
- Mineralisation
- Mononuclear cell infiltration
- Pannus formation
- Articular cartilage destruction