Difference between revisions of "Caprine Arthritis Encephalitis Virus"
Jump to navigation
Jump to search
| Line 11: | Line 11: | ||
*T cells induce immune complex disease | *T cells induce immune complex disease | ||
*Causes '''encephalitis of kids''' or [[Joints Inflammatory - Pathology#In Goats|'''insidious polyarthritis of adults''']] | *Causes '''encephalitis of kids''' or [[Joints Inflammatory - Pathology#In Goats|'''insidious polyarthritis of adults''']] | ||
| − | *Also causes | + | *Also causes pneumonia |
====Epidemiology==== | ====Epidemiology==== | ||
| Line 30: | Line 30: | ||
===Caprine Arthritis-Encephalitis (CAE)=== | ===Caprine Arthritis-Encephalitis (CAE)=== | ||
| − | *Caused by [[Retroviridae|retrovirus (lentivirus)]] similar to [[ | + | *Caused by [[Retroviridae|retrovirus (lentivirus)]] similar to [[Visna-Maedi Virus|Maedi Visna]] in sheep described above |
*Two forms: | *Two forms: | ||
**Non-suppurative leukoencephalomyelitis in young goats and kids | **Non-suppurative leukoencephalomyelitis in young goats and kids | ||
Revision as of 12:59, 20 July 2010
 |
This article is still under construction. |
CAEV
Antigenicity
- Serologically related to Visna-Maedi with antigenic and genetic envelope differences
Hosts
- Goats
Pathogenesis
- T cells induce immune complex disease
- Causes encephalitis of kids or insidious polyarthritis of adults
- Also causes pneumonia
Epidemiology
- Transfer via milk and colostrum, particularly batch-mixing
- Present in 10% of UK herds
- Clinical disease is rare
Diagnosis
- Visna-Maedi serology (ELISA) test can be used to remove positive stock
Control
- Separate kids from virus positive mothers at birth
- Treat mother's colostrum (56 deg for 1 hour)
- Rear on artificial milk
Caprine Arthritis-Encephalitis (CAE)
- Caused by retrovirus (lentivirus) similar to Maedi Visna in sheep described above
- Two forms:
- Non-suppurative leukoencephalomyelitis in young goats and kids
- Chronic, non-suppurative arthritis-synovitis in adult goats
- Also causes interstitial pneumonia which tends to be obscured by other clinical signs
- Gross pathology:
- Mainly caudal lobes
- Lungs are firm, grey-pink with grey-white focal lesions on cut surface
- Micro pathology:
- Thickened alveolar wall
- Lymphocyte infiltration and type II pneumocyte hyperplasia
- Can be confused with or coexisting with Parasitic pneumonia
- Arthritis is commonly the main expression
- Large limb joints are thickened
- Carpal hygroma is often present
- Subcutaneous cystic swelling on cranial surface of the knee, contains serous fluid
- In advanced cases
- Synovial villus hypertrophy
- Necrosis
- Mineralisation
- Mononuclear cell infiltration
- Pannus formation
- Articular cartilage destruction