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*Starts as a pyemia and localises in varius tissues, including the lung as abscessation
*Starts as a pyemia and localises in varius tissues, including the lung as abscessation
**Encapsulated abscesses contain yellow, caseous or creamy pus
**Encapsulated abscesses contain yellow, caseous or creamy pus
*Pathogenesis:
**Infection via ingestion, inhalation or skin wounds from environment
**Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
**Strain virulence and host immunosuppression important
*Clinical infections:
**Opportunistic infection with stress and immunosuppression predisposing to disease
**Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
**Chronic, debilitating, progressive disease with long incubation period
**Many animal species susceptible
**Referred to as pseudoglanders in horses
*Diagnosis:
**Specimens: pus from abscesses, affected tissues, blood
**Fluorescent antibody technique on tissue smears
**Blood agar and MacConkey agar plates, incubated aerobically
**Colonies have musty smell
**Lactose fermentation on MacConkey
**Slide agglutination
**ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
*Treatment/control: slaughter of infected animals where exotic
*[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|Pneumonia]] and arthritis are the most common presentation
*[[Lungs Inflammatory - Pathology#Infectious causes of pneumonia|Pneumonia]] and arthritis are the most common presentation
[[Category:Respiratory_Bacterial_Infections]][[Category:Sheep]]
[[Category:Respiratory_Bacterial_Infections]][[Category:Sheep]]
[[Category:To_Do_-_Clinical]]