Difference between revisions of "Equine Severe Combined Immune Deficiency"
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(Created page with "(Equine SCID) *Autosomal recessive *Occurs in 2-3% of Arabian foals *Defect in DNA-dependent protein kinase gene **Gene codes for a DNA repair enzyme involved in V(D)J recombinat...") |
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[[Category:Primary Adaptive Immunity Deficiencies]] | [[Category:Primary Adaptive Immunity Deficiencies]] | ||
[[Category:To Do - Blood]] | [[Category:To Do - Blood]] | ||
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Revision as of 13:54, 12 August 2010
(Equine SCID)
- Autosomal recessive
- Occurs in 2-3% of Arabian foals
- Defect in DNA-dependent protein kinase gene
- Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
- No functional B cells or T cells
- Foals develop infections (usually around 8 weeks of age as maternal antibody in colostrum wanes around this time)
- Foals usually die from bronchopneumonia