Difference between revisions of "Equine Infectious Anemia"
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==Description== | ==Description== | ||
| − | Equine Infectious Anemia (EIA) is an exotic viral disease affecting horses, donkeys and mules. It is caused by an equid-specific lentivirus in the retrovirus family | + | Equine Infectious Anemia (EIA) is an exotic viral disease affecting horses, donkeys and mules. It is caused by Equine Infectious Anemia Virus (EIAV), an equid-specific lentivirus in the retrovirus family that is closely to related to HIV in humans. |
====Pathogenesis==== | ====Pathogenesis==== | ||
| + | The virus is usually transmitted through large biting flies such as horseflies (Tabanid spp) or stable flies (Stomoxys calcitrans). Blood is transferred from infected horses when the flies feed, Infection with EIA results in an acute phase of infection followed by recurrent episodes that usually susbide after a period of time. Affected horses become persistently infected, lifelong carriers of the disease. | ||
*Virus coats red blood cells and thrombocytes | *Virus coats red blood cells and thrombocytes | ||
*'''Type III Immune complex disease''' develops | *'''Type III Immune complex disease''' develops | ||
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==Clinical signs== | ==Clinical signs== | ||
| − | The incubation period of the disease ranges from 10 to over 45 days and initial clinical signs may be vague or unnoticed. | + | The incubation period of the disease ranges from 10 to over 45 days and initial clinical signs may be vague or unnoticed. IAnimals may be affected acutely, chronically or sub-clinically and clinical signs vary according to the stage of the disease. Inapparent carriers may be clinically normal. The history may include a period of inappetance, fever, lethargy, depression or weight loss. Clinical signs may include petechial haemorrhages of the mucosae, oedema of the head, limbs and trunk, pyrexia, poor body condition and pale mucous membranes. |
==Diagnosis== | ==Diagnosis== | ||
Revision as of 20:22, 27 August 2010
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This article is still under construction. |
Also known as: EIA, Swamp Fever
Description
Equine Infectious Anemia (EIA) is an exotic viral disease affecting horses, donkeys and mules. It is caused by Equine Infectious Anemia Virus (EIAV), an equid-specific lentivirus in the retrovirus family that is closely to related to HIV in humans.
Pathogenesis
The virus is usually transmitted through large biting flies such as horseflies (Tabanid spp) or stable flies (Stomoxys calcitrans). Blood is transferred from infected horses when the flies feed, Infection with EIA results in an acute phase of infection followed by recurrent episodes that usually susbide after a period of time. Affected horses become persistently infected, lifelong carriers of the disease.
- Virus coats red blood cells and thrombocytes
- Type III Immune complex disease develops
- Non-neutralizing antibody and complement lyse RBC's, causing:
- Jaundice
- Vasculitis
- Hemorrhage
- Diarrhoea
- Loss of condition
- Oedema
- High mortality
Epidemiology
- Notifiable in UK but endemic in parts of the US
- Animals can be carriers for years despite being antibody-positive
- Transfer is mechanical via vectors:
- Mosquitoes transfer infected macrophages
- Also transferred via infected needles, semen and milk
- Infected horses have lifetime latent infection of macrophages with recurring bouts of virus when immunocompromised
Clinical signs
The incubation period of the disease ranges from 10 to over 45 days and initial clinical signs may be vague or unnoticed. IAnimals may be affected acutely, chronically or sub-clinically and clinical signs vary according to the stage of the disease. Inapparent carriers may be clinically normal. The history may include a period of inappetance, fever, lethargy, depression or weight loss. Clinical signs may include petechial haemorrhages of the mucosae, oedema of the head, limbs and trunk, pyrexia, poor body condition and pale mucous membranes.
Diagnosis
- Coggins test required for horse movement in the US:
- Serum antibody by immunodiffusion in infected horse spleen
Control
- Slaughter of infected animal
- 2 clear Coggins tests of all horses before movement allowed
- Vector control: stabling, etc.