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Coagulation Factor Deficiency (view source)

Revision as of 11:08, 29 September 2010

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→‎Von Willebrand's Disease
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Von Willebrand's Disease is an inherited autosomal recessive trait. It is incompletely dominant, so there is variable expression. It can present as purpura and/or prolonged bleeding times. Pathologically, there is reduced platelet adhesiveness and low Factor XIII levels.
 
Von Willebrand's Disease is an inherited autosomal recessive trait. It is incompletely dominant, so there is variable expression. It can present as purpura and/or prolonged bleeding times. Pathologically, there is reduced platelet adhesiveness and low Factor XIII levels.
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The disease can be assessed by the measurement of Von Willebrand Factor protein levels.
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The disease can be assessed by the measurement of Von Willebrand Factor protein levels; levels are low in affected animals. The Von Willebrand Factor protein bind to Factor VIII, and is synthesised in endothelial cells and megakaryocytes and stored in platelets.   
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** A Factor VIII-related protein.
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** Synthesised in endothelial cells and megakaryocytes.
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** Stored in platelets.   
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** Levels are low in affected animals.
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==Factor I ==
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'''Deficiency states of other factors have been recorded sporadically as follows:'''
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====Factor I ====
      
* Factor 1 is fibrinogen.
 
* Factor 1 is fibrinogen.
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** Depletion by intravascular coagulation.
 
** Depletion by intravascular coagulation.
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====Factor II ====
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==Factor II ==
    
* Factor II is part of the prothrombin complex.
 
* Factor II is part of the prothrombin complex.
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*** Competitively inhibits Vitamin K  in the liver, where the above Factors are synthesised.
 
*** Competitively inhibits Vitamin K  in the liver, where the above Factors are synthesised.
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====Factor IV ====
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==Factor IV ==
    
* Factor IV is calcium.
 
* Factor IV is calcium.
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** There is therefore no bleeding defect associated with hypocalcaemia.
 
** There is therefore no bleeding defect associated with hypocalcaemia.
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====Factor VII====
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==Factor VII==
    
* Factor VII is Proconvertin.
 
* Factor VII is Proconvertin.
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* Deficiencies may also occur associated with [[Liver - Anatomy & Physiology|liver]] disease and in dicoumarol poisoning.
 
* Deficiencies may also occur associated with [[Liver - Anatomy & Physiology|liver]] disease and in dicoumarol poisoning.
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====Factor VIII ====
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==Factor VIII ==
    
* Factor VIII is known as antihaemophilic factor (AHF).
 
* Factor VIII is known as antihaemophilic factor (AHF).
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* Haematomas and haemarthrosis are common lesions.
 
* Haematomas and haemarthrosis are common lesions.
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====Factor IX ====
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==Factor IX ==
    
* Factor IX is Christmas Factor.
 
* Factor IX is Christmas Factor.
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*** Similar to Factor VIII deficiency.
 
*** Similar to Factor VIII deficiency.
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====Factor XI====
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==Factor XI==
    
* Factore XI is Plasma Thromboplastin Antecedent.
 
* Factore XI is Plasma Thromboplastin Antecedent.
 
* Deficiency has been reported in a cow, and reduced levels in the horse.
 
* Deficiency has been reported in a cow, and reduced levels in the horse.
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====Factor XII====
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==Factor XII==
    
* Factor XII is Hageman Factor.
 
* Factor XII is Hageman Factor.
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