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==Introduction==
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Factor deficiencies are often the result of congenital deficiency in one or more of the coagulation factors. Deficiencies lead to ineffective blood clotting and development of a disease syndrome characterized by excessive bleeding - deficiencies are often detected following trauma or surgery. Cccasionally bleeding may be spontaneous (e.g. into alimentary or urinary tracts). Deficiencies are often seen as familial inherited problems. Haemophilia (factor VIII deficiency) is probably the best understood condition.
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'''Factor deficiencies''' are often the result of congenital deficiency in one or more of the coagulation factors. 
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==Von Willebrand's Disease==
** Gives ineffective blood clotting and development of a disease syndrome characterized by excessive bleeding. S
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This condition is seen in the dog, most frequently in Scottish Terriers and Chesapeake Bay Retrievers. It has become more prevalent recently in Dobermanns, Setters and German Shepherd dogs. A similar disease has been recorded in the pig.  
*** Such bleeding is usually detected following trauma or surgery.
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**** May occasionally be spontaneous (e.g. into alimentary or urinary tracts).
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Von Willebrand's Disease is an inherited autosomal recessive trait. It is incompletely dominant, so there is variable expression.
** Often seen as familial inherited problems.
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===Presentation===
*** E.g. haemophilia
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* Purpura.
 
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* Prolonged bleeding time.
 
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* Reduced platelet adhesiveness.
===Diseases associated with coagulation factor defects===
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* Low Factor XIII levels.
 
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* Most cases of "factor disease" in animals are similar to those studied in man.
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** Congenital.
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** Based on familial occurence.
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** Clotting biochemistry is similar in man and animals.
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* Most investigations have been carried out in the dog.
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* Haemophilia (factor VIII deficiency) is probably the best understood condition.
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====Von Willebrand's Disease====
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* Seen in the dog.
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** Most common in Scottish Terriers and Chesapeake Bay Retrievers.
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** Has been seen more recently in Dobermanns, Setters and German Shepherd dogs.
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** A similar disease has been recorded in the pig.   
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* Von Willebrand's Disease is an inherited autosomal recessive trait.
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** It is incompletely dominant, so there is variable expression.
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* '''Presentation'''
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** Purpura.
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** Prolonged bleeding time.
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** Reduced platelet adhesiveness.
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** Low Factor XIII levels.
   
* The disease can be assessed by the measurement of Von Willebrand Factor protein levels.
 
* The disease can be assessed by the measurement of Von Willebrand Factor protein levels.
 
** A Factor VIII-related protein.
 
** A Factor VIII-related protein.
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