Difference between revisions of "Joints Degenerative - Pathology"

Revision as of 15:44, 3 March 2011

Spondylosis (Image sourced from Bristol Biomed Image Archive with permission)

Often in bulls and dogs, occurs also in horses, cats and pigs
Osteophyte formation on ventral aspect of vertebrae
- Often around lumbar region
- Adjacent to intervertebral spaces
- Varies in size - small spurs -> 'bridges' between vertebrae
- May extend over few vertebrae
Pathogenesis:
- Repeated abnormal movement between joints -> stress
- -> Degeneration of annulus fibrosis
- -> Osteophyte formation
In dogs usually no symptoms
In bulls may cause inability to mount
In severe cases repeated damage may progress to recurrent posterior weakness and ataxia in conjuction with fractures of spondylitic and vertebral bone

Autoantibodies against collagens seen in the joint fluid – no relationship to the disease (ie: not an autoimmune disease) – can be seen in any joint disease

From glucocorticoids injected into joint as antiinflammatories
Injection sometimes causes rapid progression of degeneration
Glucocortyicois suppress anabolic effect of chondrocytes -> reduction of cartilage matrix syhthesis -> proteoglycan depletion -> slower repair

@@ Line 38: / Line 38: @@
-===Cervicospinal arthropathy===
+===[[Cervicospinal Arthropathy]]===
-* = "'''Wobbler'''" in horses
-*Usually presents in first two years of life
-*Mainly in fast growing thouroughbreds
-*Most common site is C3-C4, can occur anywhere
-*Abnormal laxity between the vertebrae + cervical vertebral malformation may be evident
-*[[Musculoskeletal Terminology - Pathology|Osteophyte formation]] at edges of synovial components of joint
-*Some due to stenosis of neural canal later in life (1-4 years of age)
-*Clinical signs:
-**Ataxia - hindlimbs more affected
-*Presumed cause is rapid growth
-[[Category:Joints - Degenerative Pathology]]